![](/images/graphics-bg.png)
Clinical Impact of CD25CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients
Joint Authors
Ibrahim, L.
El-Ghonemy, M.
El Agdar, Mohamed
Khaled, Nada
Aref, Salah
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
This study aimed to determine the clinical impact of CD25+/CD123+ coexpression in adult B-cell acute lymphoblastic leukemia (B-ALL) cases.
One hundred and twenty newly diagnosed B-ALL patients (≤60 years old) were included in this study.
CD123 and CD25 expression on leukemic blast cells were assessed using flow cytometry.
CD25+/CD123+ coexpression was detected in 40/120 B-ALL patients (33.3%).
All B-ALL patients showed CD25+/CD123+ coexpression had lower induction of remission response and shorter overall survival as compared to B-ALL cases lacking coexpression.
In conclusion, CD25+/CD123+ positive coexpression is a reliable flow cytometry marker for prediction of the outcome of adult B-ALL patients and could be used as a novel parameter for risk stratification of adult B-ALL cases.
American Psychological Association (APA)
Aref, Salah& El Agdar, Mohamed& Khaled, Nada& Ibrahim, L.& El-Ghonemy, M.. 2020. Clinical Impact of CD25CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients. Advances in Hematology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1126452
Modern Language Association (MLA)
Aref, Salah…[et al.]. Clinical Impact of CD25CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients. Advances in Hematology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1126452
American Medical Association (AMA)
Aref, Salah& El Agdar, Mohamed& Khaled, Nada& Ibrahim, L.& El-Ghonemy, M.. Clinical Impact of CD25CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients. Advances in Hematology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1126452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126452