Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon
Joint Authors
Pieme, Anatole Constant
Kubong, Landry Nguepnkep
Nya Biapa, Prosper Cabral
Chetcha, Bernard
Yanou-Njintang, Nicolas
Moor Ama, Vicky Jocelyne
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa.
The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative stress in a group of patients living with SCA in Cameroon.
Methods.
A group of 85 homozygote SS patients (male and female) were enrolled at the Central hospital of Yaounde in Cameroon between May and October 2017.
After informed consent through the signature of a consent form was obtained, the plasma was collected to determine the lipid profile while the lysate solution of RBC was used to explore some markers of oxidative stress using spectrophotometric methods.
Results.
Among the 85 patients included in our study, the mean age was 30 ± 5 years and the female to male ratio was 0.97.
The majority of the patients (52–81%) had dyslipidaemia, and 22.4% of the patients demonstrated a higher level of atherogenic index of plasma.
The patients with a higher level of total cholesterol (TC) (>240 mg/dl) and low-density lipoprotein (LDL-C) (>159 mg/dl) had at least 1,334 fold of malondialdeheyde (MDA) concentration than those with normal level.
Also in the same patients, the higher atherogenic plasmatic index (API) significantly (p<0.05) increased with the concentration of MDA.
Except HDL-C, the other parameters of lipid profile had significant (p<0.05) correlation with reduced glutathione (GsH) and total antioxidant capacity (TAC).
The significant (p<0.05) and linear regression was found between the increased MDA and higher API.
Conclusion.
Dyslipidemia increases oxidative stress and higher API which leads to coronary vascular disease in patients with SCA.
American Psychological Association (APA)
Kubong, Landry Nguepnkep& Nya Biapa, Prosper Cabral& Chetcha, Bernard& Yanou-Njintang, Nicolas& Moor Ama, Vicky Jocelyne& Pieme, Anatole Constant. 2020. Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon. Advances in Hematology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1126455
Modern Language Association (MLA)
Kubong, Landry Nguepnkep…[et al.]. Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon. Advances in Hematology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1126455
American Medical Association (AMA)
Kubong, Landry Nguepnkep& Nya Biapa, Prosper Cabral& Chetcha, Bernard& Yanou-Njintang, Nicolas& Moor Ama, Vicky Jocelyne& Pieme, Anatole Constant. Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon. Advances in Hematology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1126455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126455