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Circulating MicroRNA-4739 May Be a Potential Biomarker of Critical Limb Ischemia in Patients with Diabetes
Joint Authors
Li, Juyi
Wang, Zhongjing
Deng, Aiping
Cheng, Biao
Wang, Xiu-fang
Zhang, Hong-mei
Liu, Shu-fen
Chen, Li-sha
Huang, Wen-jing
Liu, Jue
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Critical limb ischemia (CLI) is the most severe manifestation of peripheral artery disease, which is common but rarely diagnosed.
Noninvasive biomarkers are urgently required to assist in the diagnosis of CLI.
Accumulating evidence indicates that miRNAs play an important role in the development of various diseases.
In this study, microarray profiling revealed 11 miRNAs with significantly altered expression in four T2DM patients with CLI compared with that in four sex- and age-matched T2DM patients without CLI.
In independent cohorts, qRT-PCR validation confirmed the increased miRNA-4739 level in patients with CLI versus patients without CLI.
miRNA-4739 levels increased with FPG and HbA1c (all P < 0.05).
After adjusting for the risk factors, miRNA-4739 levels were found to be associated with an increased odds ratio (OR) of T2DM with CLI (OR =12.818, 95% confidence intervals (CI) 1.148 to 143.143, P = 0.038).
ROC curve analysis revealed that the area under the curve (AUC) of miR-4739+confounding risk factors was 0.94 (95% CI 0.891 to 0.998, P < 0.001), which was higher than that of confounding risk factors (AUC 0.94 vs.
0.91, 95% CI -0.122 to 0.060, P > 0.05) and of miR-4739 (AUC 0.94 vs.
0.69, 95% CI -0.399 to -0.101, P < 0.001), respectively.
We conclude that elevated plasma miRNA-4739 levels are independently associated with CLI in T2DM patients.
miRNA-4739 is implicated as a novel diagnostic marker and a potential therapeutic target for CLI in diabetes.
American Psychological Association (APA)
Li, Juyi& Cheng, Biao& Wang, Xiu-fang& Wang, Zhongjing& Zhang, Hong-mei& Liu, Shu-fen…[et al.]. 2018. Circulating MicroRNA-4739 May Be a Potential Biomarker of Critical Limb Ischemia in Patients with Diabetes. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126456
Modern Language Association (MLA)
Li, Juyi…[et al.]. Circulating MicroRNA-4739 May Be a Potential Biomarker of Critical Limb Ischemia in Patients with Diabetes. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1126456
American Medical Association (AMA)
Li, Juyi& Cheng, Biao& Wang, Xiu-fang& Wang, Zhongjing& Zhang, Hong-mei& Liu, Shu-fen…[et al.]. Circulating MicroRNA-4739 May Be a Potential Biomarker of Critical Limb Ischemia in Patients with Diabetes. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126456