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Focused Ultrasound Effects on Osteosarcoma Cell Lines
Joint Authors
Alessandro, Riccardo
Raimondi, Lavinia
Fini, Milena
Carina, Valeria
Stassi, Giorgio
De Luca, Angela
Giavaresi, Gianluca
Massimo, Midiri
Pagani, S.
Agnese, Valentina
Costa, Viviana
Scoarughi, Gian Luca
Corso, Cristiano
Bellavia, Daniele
Barbato, Gaetano
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
MRI guided Focused Ultrasound (MRgFUS) has shown to be effective therapeutic modality for non-invasive clinical interventions in ablating of uterine fibroids, in bone metastasis palliative treatments, and in breast, liver, and prostate cancer ablation.
MRgFUS combines high intensity focused ultrasound (HIFU) with MRI images for treatment planning and real time thermometry monitoring, thus enabling non-invasive ablation of tumor tissue.
Although in the literature there are several studies on the Ultrasound (US) effects on cell in culture, there is no systematic evidence of the biological effect of Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) treatment on osteosarcoma cells, especially in lower dose regions, where tissues receive sub-lethal acoustic power.
The effect of MRgFUS treatment at different levels of acoustic intensity (15.5-49 W/cm2) was investigated on Mg-63 and Saos-2 cell lines to evaluate the impact of the dissipation of acoustic energy delivered outside the focal area, in terms of cell viability and osteogenic differentiation at 24 h, 7 days, and 14 days after treatment.
Results suggested that the attenuation of FUS acoustic intensities from the focal area (higher intensities) to the “far field” (lower intensities) zones might determine different osteosarcoma cell responses, which range from decrease of cell proliferation rates (from 49 W/cm2 to 38.9 W/cm2) to the selection of a subpopulation of heterogeneous and immature living cells (from 31.1 W/cm2 to 15.5 W/cm2), which can clearly preserve bone tumor cells.
American Psychological Association (APA)
Agnese, Valentina& Costa, Viviana& Scoarughi, Gian Luca& Corso, Cristiano& Carina, Valeria& De Luca, Angela…[et al.]. 2019. Focused Ultrasound Effects on Osteosarcoma Cell Lines. BioMed Research International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1126459
Modern Language Association (MLA)
Agnese, Valentina…[et al.]. Focused Ultrasound Effects on Osteosarcoma Cell Lines. BioMed Research International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1126459
American Medical Association (AMA)
Agnese, Valentina& Costa, Viviana& Scoarughi, Gian Luca& Corso, Cristiano& Carina, Valeria& De Luca, Angela…[et al.]. Focused Ultrasound Effects on Osteosarcoma Cell Lines. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1126459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126459