Burkholderia cenocepacia Induces Macropinocytosis to Enter Macrophages
Joint Authors
Ortiz-Navarrete, Vianney
Sánchez-Gómez, Concepción
Rosales-Reyes, Roberto
Santos-Preciado, José Ignacio
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Burkholderia cenocepacia is an opportunistic pathogen that infects individuals with cystic fibrosis, chronic granulomatous disease, and other immunocompromised states.
B.
cenocepacia survives in macrophages in membrane-bound vacuoles; however, the mechanism by which B.
cenocepacia gains entry into macrophages remains unknown.
After macrophage internalization, survival of B.
cenocepacia within a bacteria-containing membrane vacuole (BcCV) is associated with its ability to arrest the maturation of the BcCV.
In this study, we show that B.
cenocepacia induces localized membrane ruffling, macropinocytosis, and macropinosomes-like compartments upon contact with the macrophage.
The Type 3 Secretion System (T3SS) of B.
cenocepacia contributes to macrophage entry and macropinosome-like compartment formation.
These data demonstrate the ability of Burkholderia to enter macrophages through the induction of macropinocytosis.
American Psychological Association (APA)
Rosales-Reyes, Roberto& Sánchez-Gómez, Concepción& Ortiz-Navarrete, Vianney& Santos-Preciado, José Ignacio. 2018. Burkholderia cenocepacia Induces Macropinocytosis to Enter Macrophages. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126487
Modern Language Association (MLA)
Rosales-Reyes, Roberto…[et al.]. Burkholderia cenocepacia Induces Macropinocytosis to Enter Macrophages. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1126487
American Medical Association (AMA)
Rosales-Reyes, Roberto& Sánchez-Gómez, Concepción& Ortiz-Navarrete, Vianney& Santos-Preciado, José Ignacio. Burkholderia cenocepacia Induces Macropinocytosis to Enter Macrophages. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126487