Carbon Dioxide Laser Microsurgery versus Low-Temperature Plasma Radiofrequency Ablation for T1a Glottic Cancer: A Single-Blind Randomized Clinical Trial
Joint Authors
Zhang, Yan
Wang, Binru
Sun, Guangbin
Zhang, Guoliang
Lu, Ling
Liang, Gengtian
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Very few studies have been conducted to compare carbon dioxide laser microsurgery (CO2-LS) with low-temperature plasma radiofrequency ablation (LTP-RFA) in treating T1a glottic cancer.
Therefore, we conducted this study to compare the efficacy of CO2-LS and LTP-RFA to define a superior therapeutic modality for T1a glottic cancer.
Methods.
Patients (n=131) with T1a glottic cancer were recruited between January 2010 and September 2014.
The included patients were randomly assigned to either receive CO2-LS (n=65) or LTP-RFA (n=66).
We conducted the following multidimensional vocal assessments: (i) videostroboscopic evaluation; (ii) auditory-perceptual evaluation; (iii) aerodynamics/ efficiency; (iv) acoustics; and (v) self-assessment questionnaires.
Meanwhile, the surgery time and three-year overall survival rates in two groups were recorded.
The predefined primary endpoint was overall survival, and the minimum follow-up time was set to six months.
Results.
After treatment, we found that the structure and vibration of vocal cord might recover more quickly in patients receiving LTP-RFA than in patients receiving CO2-LS, and moreover, the patients in the LTP-RFA group had the better vocal functions.
Meanwhile, the surgery time was significantly less in the LTP-RFA group (8.83±1.59 minutes) than in the CO2-LS group (12.49±1.40 minutes) (p<0.00001).
In addition, the two intervention methods had the similar three-year overall survival rates (94% versus 96%, p=0.58).
Conclusion.
These results indicated that both LTP-RFA and CO2-LS could effectively treat T1a glottic cancer, and LTP-RFA might have some advantages in voice function.
Limited by the relatively small sample size, future studies were needed to validate our conclusion.
American Psychological Association (APA)
Zhang, Yan& Wang, Binru& Sun, Guangbin& Zhang, Guoliang& Lu, Ling& Liang, Gengtian. 2018. Carbon Dioxide Laser Microsurgery versus Low-Temperature Plasma Radiofrequency Ablation for T1a Glottic Cancer: A Single-Blind Randomized Clinical Trial. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126503
Modern Language Association (MLA)
Zhang, Yan…[et al.]. Carbon Dioxide Laser Microsurgery versus Low-Temperature Plasma Radiofrequency Ablation for T1a Glottic Cancer: A Single-Blind Randomized Clinical Trial. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126503
American Medical Association (AMA)
Zhang, Yan& Wang, Binru& Sun, Guangbin& Zhang, Guoliang& Lu, Ling& Liang, Gengtian. Carbon Dioxide Laser Microsurgery versus Low-Temperature Plasma Radiofrequency Ablation for T1a Glottic Cancer: A Single-Blind Randomized Clinical Trial. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126503