Toxoplasma gondii Modulates the Host Cell Responses: An Overview of Apoptosis Pathways
Joint Authors
Courtioux, Bertrand
Mammari, Nour
Halabi, Mohamad Adnan
Yaacoub, Souha
Chlala, Hilda
Dardé, Marie-Laure
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Infection with Toxoplasma gondii has a major implication in public health.
Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect all nucleated cells belonging to a wide range of host species.
One of the particularities of this parasite is its invasion and persistence in host cells of immunocompetent people.
This infection is usually asymptomatic.
In immunocompromised patients, the infection is severe and symptomatic.
The mechanisms by which T.
gondii persists are poorly studied in humans.
In mouse models, many aspects of the interaction between the parasite and the host cells are being studied.
Apoptosis is one of these mechanisms that could be modulated by Toxoplasma to persist in host cells.
Indeed, Toxoplasma has often been implicated in the regulation of apoptosis and viability mechanisms in both human and murine infection models.
Several of these studies centered on the regulation of apoptosis pathways have revealed interference of this parasite with host cell immunity, cell signalling, and invasion mechanisms.
This review provides an overview of recent studies concerning the effect of Toxoplasma on different apoptotic pathways in infected host cells.
American Psychological Association (APA)
Mammari, Nour& Halabi, Mohamad Adnan& Yaacoub, Souha& Chlala, Hilda& Dardé, Marie-Laure& Courtioux, Bertrand. 2019. Toxoplasma gondii Modulates the Host Cell Responses: An Overview of Apoptosis Pathways. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126509
Modern Language Association (MLA)
Mammari, Nour…[et al.]. Toxoplasma gondii Modulates the Host Cell Responses: An Overview of Apoptosis Pathways. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1126509
American Medical Association (AMA)
Mammari, Nour& Halabi, Mohamad Adnan& Yaacoub, Souha& Chlala, Hilda& Dardé, Marie-Laure& Courtioux, Bertrand. Toxoplasma gondii Modulates the Host Cell Responses: An Overview of Apoptosis Pathways. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126509
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126509