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Tazarotene-Induced Gene 1 (TIG1) Interacts with Serine Protease Inhibitor Kazal-Type 2 (SPINK2) to Inhibit Cellular Invasion of Testicular Carcinoma Cells
Joint Authors
Tsai, Fu-Ming
Wang, Lu-Kai
Wang, Chun-Hua
Shyu, Rong-Yaun
Wu, Chang-Chieh
Chen, Mao-Liang
Kuo, Chan-Yen
Lee, Ming-Cheng
Lin, Yi-Ying
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tazarotene-induced gene 1 (TIG1) encodes a protein that is a retinoid-regulated tumor suppressor.
TIG1 is expressed in most normal tissues, and downregulation of TIG1 expression in multiple cancers is caused by promoter hypermethylation.
Kazal-type serine protease inhibitor-2 (SPINK2) is a serine protease inhibitor, and the SPINK protein family has been shown to inhibit the expression of urokinase-type plasminogen activator (uPA).
In addition, increased levels of uPA and the uPA receptor were observed in testicular cancer tissues.
This study demonstrated that TIG1 interacts with SPINK2 in NT2/D1 testicular carcinoma cells.
TIG1 and SPINK2 were highly expressed in normal testis tissues, while low expression levels of TIG1 and SPINK2 were found in testicular cancer tissues.
TIG1 inhibited cell invasion, migration, and epithelial–mesenchymal transition (EMT) of NT2/D1 cells.
SPINK2 enhanced TIG1-regulated uPA activity and EMT suppression, while silencing SPINK2 alleviated TIG1-mediated EMT regulation, cell migration, and invasion.
Therefore, the results suggest that the interaction between TIG1 and SPINK2 plays an important role in the inhibition of testicular cancer cell EMT, and suppression is mediated through downregulation of the uPA/uPAR signaling pathway.
American Psychological Association (APA)
Shyu, Rong-Yaun& Wang, Chun-Hua& Wu, Chang-Chieh& Wang, Lu-Kai& Chen, Mao-Liang& Kuo, Chan-Yen…[et al.]. 2019. Tazarotene-Induced Gene 1 (TIG1) Interacts with Serine Protease Inhibitor Kazal-Type 2 (SPINK2) to Inhibit Cellular Invasion of Testicular Carcinoma Cells. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126523
Modern Language Association (MLA)
Shyu, Rong-Yaun…[et al.]. Tazarotene-Induced Gene 1 (TIG1) Interacts with Serine Protease Inhibitor Kazal-Type 2 (SPINK2) to Inhibit Cellular Invasion of Testicular Carcinoma Cells. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1126523
American Medical Association (AMA)
Shyu, Rong-Yaun& Wang, Chun-Hua& Wu, Chang-Chieh& Wang, Lu-Kai& Chen, Mao-Liang& Kuo, Chan-Yen…[et al.]. Tazarotene-Induced Gene 1 (TIG1) Interacts with Serine Protease Inhibitor Kazal-Type 2 (SPINK2) to Inhibit Cellular Invasion of Testicular Carcinoma Cells. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126523