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Pinelliae Rhizoma Praeparatum Cum Alumine Extract: Sedative and Hypnotic Effects in Mice and Component Compounds
Joint Authors
Nie, Bo
Lin, Sisi
Song, Ke
Ye, Ren
Yuan, Zhengzhong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pinelliae Rhizoma Praeparatum Cum Alumine (PRPCA) is useful for eliminating dampness and phlegm in clinical settings, targeting the main mechanisms of insomnia as defined in traditional Chinese medicine.
However, little is known regarding the sedative and hypnotic effects of PRPCA.
In the present study, we examined the sedative effects of PRPCA via a locomotor activity test and aimed to determine the most appropriate concentration of PRPCA for achieving these effects.
The strongest sedative effects were observed at a PRPCA concentration of 0.45 g/ml.
In addition, we investigated the hypnotic effects of PRPCA and its role in promoting sleep via sleep monitoring and vigilance state analysis.
PRPCA increased rapid eye movement (REM) sleep and non-REM (NREM) sleep while decreasing wakefulness.
In addition, PRPCA decreased the number of bouts of wakefulness (16–32 s and 32–64 s) and increased the number of bouts of NREM sleep (128–256 s).
Furthermore, we identified a total of 32 component compounds via chromatography and mass spectrometry.
Hence, the current work provides valuable information regarding the sedative and hypnotic effects of PRPCA and its regulatory mechanisms in promoting sleep.
American Psychological Association (APA)
Lin, Sisi& Nie, Bo& Song, Ke& Ye, Ren& Yuan, Zhengzhong. 2019. Pinelliae Rhizoma Praeparatum Cum Alumine Extract: Sedative and Hypnotic Effects in Mice and Component Compounds. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126536
Modern Language Association (MLA)
Lin, Sisi…[et al.]. Pinelliae Rhizoma Praeparatum Cum Alumine Extract: Sedative and Hypnotic Effects in Mice and Component Compounds. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126536
American Medical Association (AMA)
Lin, Sisi& Nie, Bo& Song, Ke& Ye, Ren& Yuan, Zhengzhong. Pinelliae Rhizoma Praeparatum Cum Alumine Extract: Sedative and Hypnotic Effects in Mice and Component Compounds. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126536