UPLC-QTOF MS-Based Serum Metabolomic Profiling Analysis Reveals the Molecular Perturbations Underlying Uremic Pruritus
Joint Authors
Chai, Yifeng
Wu, Qiong
Zhang, Huan
Ding, Jia-rong
Hong, Zhan-ying
Wu, Hao
Zhu, Zhen-yu
Guo, Zhi-yong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
As one of the most troublesome complications in patients with chronic renal disease, the etiology of uremic pruritus remains unknown, and the current therapeutic approaches are limited and unsatisfactory.
To identify potential biomarkers for improving diagnosis and treatment and obtain a better understanding of the pathogenesis of uremic pruritus, we compared serum metabolome profiles of severe uremic pruritus (HUP) patients with mild uremic pruritus (LUP) patients using ultraperformance liquid chromatography-quadruple time-of-flight mass spectrometry (UPLC-QTOF MS).
Partial least squares discriminant analysis (PLS-DA) showed that the metabolic profiles of HUP patients are distinguishable from those of LUP patients.
Combining multivariate with univariate analysis, 22 significantly different metabolites between HUP and LUP patients were identified.
Nine of the 22 metabolites in combination were characterized by a maximum area-under-receiver operating characteristic curve (AUC = 0.899) with a sensitivity of 85.1% and a specificity of 83.0% distinguishing HUP and LUP.
Our results indicate that serum metabolome profiling might serve as a promising approach for the diagnosis of uremic pruritus and that the identified biomarkers may improve the understanding of pathophysiology of this disorder.
Because the 9 metabolites were phospholipids, uremic toxins, and steroids, further studies may reveal their possible role in the pathogenesis of uremic pruritus.
American Psychological Association (APA)
Wu, Qiong& Zhang, Huan& Ding, Jia-rong& Hong, Zhan-ying& Wu, Hao& Zhu, Zhen-yu…[et al.]. 2018. UPLC-QTOF MS-Based Serum Metabolomic Profiling Analysis Reveals the Molecular Perturbations Underlying Uremic Pruritus. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1126571
Modern Language Association (MLA)
Wu, Qiong…[et al.]. UPLC-QTOF MS-Based Serum Metabolomic Profiling Analysis Reveals the Molecular Perturbations Underlying Uremic Pruritus. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1126571
American Medical Association (AMA)
Wu, Qiong& Zhang, Huan& Ding, Jia-rong& Hong, Zhan-ying& Wu, Hao& Zhu, Zhen-yu…[et al.]. UPLC-QTOF MS-Based Serum Metabolomic Profiling Analysis Reveals the Molecular Perturbations Underlying Uremic Pruritus. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1126571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126571