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Renal Tubular Complement 3 Deposition in Children with Primary Nephrotic Syndrome
Joint Authors
Wang, Fengying
Li, Xiaozhong
Zhu, Xueming
Chen, Qing
Jiang, Lu
Zhu, Ziqiang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
This study aimed to investigate the clinical significance of complement 3 (C3) deposition in renal tubules of children with primary nephrotic syndrome (PNS).
Methods.
The clinical and pathological characteristics of PNS were retrospectively reviewed in 99 PNS pediatric patients, who were divided into the C3 deposition and the non-C3 deposition groups.
Results.
A total of 39 patients (39.39%) had renal tubule C3 deposition.
In the C3 deposition group, the ratios of urine N-acetylglucosaminidase/creatinine (UNAG/Cr), urine β2 microglobulin/creatinine (Uβ2MG/Cr), and urine transferrin/creatinine (UTRF/Cr) were significantly higher than those of the non-C3 deposition group.
The patients of the C3 deposition group had lower serum total protein and albumin, higher cholesterol and D-dimer (DD), lower proportion of CD3+CD8+ cells, and higher proportion of CD19+CD23+ cells.
The number of the patients with interstitial fibrosis, renal cell vacuolar degeneration, renal tubular immunoglobulin deposition, and severe tubulointerstitial injury in the C3 deposition group was higher than that of the non-C3 deposition group.
The C3 deposition intensity was positively correlated with the number of recurrences.
Conclusion.
PNS pediatric patients with C3 deposition in renal tubules have more severe disease condition, tubulointerstitial injury, and recurrence suggesting a worse long-term prognosis.
American Psychological Association (APA)
Wang, Fengying& Li, Xiaozhong& Zhu, Xueming& Chen, Qing& Jiang, Lu& Zhu, Ziqiang. 2018. Renal Tubular Complement 3 Deposition in Children with Primary Nephrotic Syndrome. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126614
Modern Language Association (MLA)
Wang, Fengying…[et al.]. Renal Tubular Complement 3 Deposition in Children with Primary Nephrotic Syndrome. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126614
American Medical Association (AMA)
Wang, Fengying& Li, Xiaozhong& Zhu, Xueming& Chen, Qing& Jiang, Lu& Zhu, Ziqiang. Renal Tubular Complement 3 Deposition in Children with Primary Nephrotic Syndrome. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126614