JAZF1 Inhibits Adipose Tissue Macrophages and Adipose Tissue Inflammation in Diet-Induced Diabetic Mice
Joint Authors
Yang, Gangyi
Meng, Fanping
Lin, Yao
Yang, Min
Li, Minyan
Hao, Po
Li, Ling
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Juxtaposed with another zinc finger gene 1 (JAZF1) affects gluconeogenesis, insulin sensitivity, lipid metabolism, and inflammation, but its exact role in chronic inflammation remains unclear.
This study aimed to examine JAZF1 overexpression in vivo on adipose tissue macrophages (ATMs).
Methods.
Mouse models of high-fat diet- (HFD-) induced insulin resistance were induced using C57BL/6J and JAZF1-overexpressing (JAZF1-OX) mice.
The mice were randomized (8–10/group) to C57BL/6J mice fed regular diet (RD) (NC group), C57BL/6J mice fed HFD (HF group), JAZF1-OX mice fed RD (NJ group), and JAZF1-OX mice fed HFD (HJ group).
Adipose tissue was harvested 12 weeks later.
ATMs were evaluated by flow cytometry.
Inflammatory markers were evaluated by ELISA.
Results.
JAZF1-OX mice had lower blood lipids, blood glucose, body weight, fat weight, and inflammatory markers compared with HF mice (all P<0.05).
JAZF1 overexpression decreased ATM number and secretion of proinflammatory cytokines.
JAZF1 overexpression decreased total CD4+ T cells, active T cells, and memory T cells and increased Treg cells.
JAZF1 overexpression downregulated IFN-γ and IL-17 levels and upregulated IL-4 levels.
JAZF1 overexpression decreased MHCII, CD40, and CD86 in total ATM, CD11c+ ATM, and CD206+ ATM.
Conclusions.
JAZF1 limits adipose tissue inflammation by limiting macrophage populations and restricting their antigen presentation function.
American Psychological Association (APA)
Meng, Fanping& Lin, Yao& Yang, Min& Li, Minyan& Yang, Gangyi& Hao, Po…[et al.]. 2018. JAZF1 Inhibits Adipose Tissue Macrophages and Adipose Tissue Inflammation in Diet-Induced Diabetic Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126655
Modern Language Association (MLA)
Meng, Fanping…[et al.]. JAZF1 Inhibits Adipose Tissue Macrophages and Adipose Tissue Inflammation in Diet-Induced Diabetic Mice. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1126655
American Medical Association (AMA)
Meng, Fanping& Lin, Yao& Yang, Min& Li, Minyan& Yang, Gangyi& Hao, Po…[et al.]. JAZF1 Inhibits Adipose Tissue Macrophages and Adipose Tissue Inflammation in Diet-Induced Diabetic Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126655