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The Impact of Pathologic Upgrading of Gleason Score 7 Prostate Cancer on the Risk of the Biochemical Recurrence after Radical Prostatectomy
Joint Authors
Kim, Hyeon Hoe
Kwak, Cheol
Park, Juhyun
Yoo, Sangjun
Cho, Min Chul
Cho, Min Hyun
Jeong, Chang Wook
Ku, Ja Hyeon
Jeong, Hyeon
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate the impact of pathologic upgrading of Gleason score (GS) 7 prostate cancer on the risk of the biochemical recurrence.
Materials and Methods.
A total of 1678 patients with postoperative GS 7 prostate cancer without lymph node metastasis were reviewed retrospectively.
The patients were categorized into four groups depending on pathologic upgrading: upgraded GS 3+4, nonupgraded GS 3+4, upgraded GS 4+3, and nonupgraded GS 4+3.
Kaplan-Meier multivariate model was created.
Results.
The mean age was significantly higher in the nonupgraded GS 4+3 group than in other groups, whereas the mean prostate-specific antigen (PSA) level was lower in the upgraded GS 3+4 group.
Pathologic findings, such as extracapsular extension, seminal vesical invasion, and the surgical margin rate, were different from each other.
Five-year biochemical recurrence-free survival rate was 85%, 73%, 69%, and 60% in upgraded GS 3+4, nonupgraded GS 3+4, upgraded GS 4+3, and nonupgraded GS 4+3 group, respectively.
There was significant difference between the nonupgraded 4+3 and upgraded 4+3 group, as well as between upgraded 3+4 and nonupgraded 3+4 group.
However, the two middle patient groups, that is, the nonupgraded GS 3+4 group and the upgraded GS 4+3 group, did not show the statistical difference (Log-rank test, p value = 0.259).
Conclusion.
The information on pathologic upgrading in the biopsy reports of patients could help to provide more detailed analysis for the biochemical recurrence of GS 7 prostate cancer.
American Psychological Association (APA)
Park, Juhyun& Yoo, Sangjun& Cho, Min Chul& Cho, Min Hyun& Jeong, Chang Wook& Ku, Ja Hyeon…[et al.]. 2018. The Impact of Pathologic Upgrading of Gleason Score 7 Prostate Cancer on the Risk of the Biochemical Recurrence after Radical Prostatectomy. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126675
Modern Language Association (MLA)
Park, Juhyun…[et al.]. The Impact of Pathologic Upgrading of Gleason Score 7 Prostate Cancer on the Risk of the Biochemical Recurrence after Radical Prostatectomy. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1126675
American Medical Association (AMA)
Park, Juhyun& Yoo, Sangjun& Cho, Min Chul& Cho, Min Hyun& Jeong, Chang Wook& Ku, Ja Hyeon…[et al.]. The Impact of Pathologic Upgrading of Gleason Score 7 Prostate Cancer on the Risk of the Biochemical Recurrence after Radical Prostatectomy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126675