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Influence of Drug-Carrier Polymers on Alpha-Synucleinopathies: A Neglected Aspect in New Therapies Development
Joint Authors
Tonda-Turo, C.
Herva, M.
Chiono, V.
Spillantini, M. G.
Ciardelli, Gianluca
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Current therapeutic strategies to treat neurodegenerative diseases, such as alpha-synucleinopathies, aim at enhancing the amount of drug reaching the brain.
Methods proposed, such as intranasal administration, should be able to bypass the blood brain barrier (BBB) and even when directly intracerebrally injected they could require a carrier to enhance local release of drugs.
We have investigated the effect of a model synthetic hydrogel to be used as drug carrier on the amount of alpha-synuclein aggregates in cells in culture.
The results indicated that alpha-synuclein aggregation was affected by the synthetic polymer, suggesting the need for testing the effect of any used material on the pathological process before its application as drug carrier.
American Psychological Association (APA)
Tonda-Turo, C.& Herva, M.& Chiono, V.& Ciardelli, Gianluca& Spillantini, M. G.. 2018. Influence of Drug-Carrier Polymers on Alpha-Synucleinopathies: A Neglected Aspect in New Therapies Development. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1126696
Modern Language Association (MLA)
Tonda-Turo, C.…[et al.]. Influence of Drug-Carrier Polymers on Alpha-Synucleinopathies: A Neglected Aspect in New Therapies Development. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1126696
American Medical Association (AMA)
Tonda-Turo, C.& Herva, M.& Chiono, V.& Ciardelli, Gianluca& Spillantini, M. G.. Influence of Drug-Carrier Polymers on Alpha-Synucleinopathies: A Neglected Aspect in New Therapies Development. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1126696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126696