Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability
Joint Authors
Delgado-Martos, María Jesús
Quintana-Villamandos, Begoña
Delgado-Baeza, Emilio
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Dronedarone is recommended for the treatment of atrial fibrillation.
However, we do not know its effect on vascular remodeling.
This study was designed to assess whether dronedarone has the potential to improve the intramyocardial artery remodeling induced by chronic hypertension.
Ten-month-old male spontaneously hypertensive rats (SHR) were randomly assigned to receive dronedarone (100 mg/kg) or vehicle.
Age-matched male Wistar-Kyoto rats served as controls.
After 14 days of treatment, we studied the structure (geometry and fibrosis) of the intramyocardial artery using histological analysis.
Nitric oxide (NO) in plasma was analyzed.
In the untreated SHR, we observed a significant increase in external diameter, lumen diameter, wall width, cross-sectional area, and collagen volume density, as was expected in the experimental model.
Dronedarone induced a significant decrease in wall width, cross-sectional area, and collagen volume density in SHR-D in comparison with untreated SHR.
The values obtained in SHR-D were similar in the WKY control group.
We found significantly higher NO levels in plasma in SHR-D than in untreated SHR.
Dronedarone improves the intramyocardial artery remodeling induced by chronic hypertension in SHR through increased nitric oxide bioavailability.
American Psychological Association (APA)
Quintana-Villamandos, Begoña& Delgado-Martos, María Jesús& Delgado-Baeza, Emilio. 2019. Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability. BioMed Research International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1126700
Modern Language Association (MLA)
Quintana-Villamandos, Begoña…[et al.]. Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability. BioMed Research International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1126700
American Medical Association (AMA)
Quintana-Villamandos, Begoña& Delgado-Martos, María Jesús& Delgado-Baeza, Emilio. Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1126700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126700