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Molecular Basis of Macrolide Resistance in Campylobacter Strains Isolated from Poultry in South Korea
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We investigated the molecular mechanisms underlying macrolide resistance in 38 strains of Campylobacter isolated from poultry.
Twenty-seven strains were resistant to azithromycin and erythromycin, five showed intermediate azithromycin resistance and erythromycin susceptibility, and six showed azithromycin resistance and erythromycin susceptibility.
Four Campylobacter jejuni and six Campylobacter coli strains had azithromycin MICs which were 8–16 and 2–8-fold greater than those of erythromycin, respectively.
The A2075G mutation in the 23S rRNA gene was detected in 11 resistant strains with MICs ranging from 64 to ≥ 512 μg/mL.
Mutations including V137A, V137S, and a six-amino acid insertion (114-VAKKAP-115) in ribosomal protein L22 were detected in the C.
jejuni strains.
Erythromycin ribosome methylase B-erm(B) was not detected in any strain.
All strains except three showed increased susceptibility to erythromycin with twofold to 256-fold MIC change in the presence of phenylalanine arginine ß-naphthylamide (PAßN); the effects of PAßN on azithromycin MICs were limited in comparison to those on erythromycin MICs, and 13 strains showed no azithromycin MIC change in the presence of PAßN.
Differences between azithromycin and erythromycin resistance and macrolide resistance phenotypes and genotypes were observed even in highly resistant strains.
Further studies are required to better understand macrolide resistance in Campylobacter.
American Psychological Association (APA)
Wei, Bai& Kang, Min. 2018. Molecular Basis of Macrolide Resistance in Campylobacter Strains Isolated from Poultry in South Korea. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126713
Modern Language Association (MLA)
Wei, Bai& Kang, Min. Molecular Basis of Macrolide Resistance in Campylobacter Strains Isolated from Poultry in South Korea. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126713
American Medical Association (AMA)
Wei, Bai& Kang, Min. Molecular Basis of Macrolide Resistance in Campylobacter Strains Isolated from Poultry in South Korea. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126713