MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5

Abstract EN

Accumulated evidence indicates that miR-455-5p functions as tumor suppressor in the progression of various cancers.

However, the mechanism through which miR-455-5p influences the tumorigenesis of human prostate cancer (PCa) remains undetermined.

In this study, reanalysis of data obtained from the Memorial Sloan Kettering Cancer Center showed that miR-455-5p can be used as biomarker for PCa diagnosis and predictor of poor prognosis.

Functional assays indicated that miR-455-5p overexpression could suppress cellular proliferation, inhibit tumor growth, and trigger apoptosis by activating and cleaving caspase 3.

We experimentally verified that miR-455-5p negatively regulated the C–C motif chemokine receptor 5 (CCR5).

Overall, our data demonstrate that miR-455-5p suppressed PCa cellular proliferation and induced cell apoptosis by downregulating CCR5.

Thus, miR-455-5p may be considered a new therapeutic strategy for PCa.