Synthesis and Evaluation of Biological Activity of New Arylphosphoramidates
Joint Authors
Ouzari, Hadda
Thebti, Amal
Sanhoury, M. A. K.
Barhoumi-slimi, T.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The synthesis of new substituted arylphosphoramidates is performed in two steps through phosphorylation of the corresponding alcohols followed by aminolysis.
The formation of the desired phosphoramidates depends on the subsequent addition of the two alcohols with the amine being added at the last step.
The products were obtained in 58–95% yields.
They were characterized mainly by multinuclear (1H, 13C, 31P, and 19F) NMR and IR spectroscopy.
In addition, the antimicrobial and antiacetylcholinesterase activities were evaluated.
The results showed acetylcholinesterase activity by some compounds, whilst no significant inhibitory effect against the tested bacterial strains has been recorded.
American Psychological Association (APA)
Thebti, Amal& Sanhoury, M. A. K.& Ouzari, Hadda& Barhoumi-slimi, T.. 2018. Synthesis and Evaluation of Biological Activity of New Arylphosphoramidates. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1126748
Modern Language Association (MLA)
Thebti, Amal…[et al.]. Synthesis and Evaluation of Biological Activity of New Arylphosphoramidates. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1126748
American Medical Association (AMA)
Thebti, Amal& Sanhoury, M. A. K.& Ouzari, Hadda& Barhoumi-slimi, T.. Synthesis and Evaluation of Biological Activity of New Arylphosphoramidates. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1126748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126748
