Which Kidney Transplant Recipients Can Benefit from the Initial Tacrolimus Dose Reduction?
Joint Authors
Więcek, Andrzej
Kolonko, Aureliusz
Krzyżowska, Kinga
Giza, Piotr
Chudek, Jerzy
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Observational data suggest that the fixed initial recommended tacrolimus (Tc) dosing (0.2 mg/kg/day) results in supratherapeutic drug levels in some patients during the early posttransplant period.
The aim of the study was to analyze a wide panel of patient-related factors and their interactions which increase the risk for first Tc blood level > 15 ng/ml.
Materials and Methods.
We performed a retrospective analysis of 488 consecutive adult kidney transplant recipients who were initially treated with triple immunosuppressive regimen containing tacrolimus twice daily.
The analysis included the first assessment of Tc trough blood levels and several demographic, anthropometric, laboratory, and comedication data.
Results.
The multiple logistic regression analysis showed that age > 55 years, BMI > 24.6 kg/m2, blood hemoglobin concentration > 9.5 g/dl, and the presence of anti-HCV antibodies independently increased the risk for first Tc level > 15 ng/ml.
The relative risk (RR) for first tacrolimus level > 15 ng/ml was 1.88 (95% CI 1.35–2.64, p<0.001) for patients with one risk factor and 2.81 (2.02–3.89, p<0.001) for patients with two risk factors.
Conclusions.
Initial tacrolimus dose reduction should be considered in older, overweight, or obese kidney transplant recipients and in subjects with anti-HCV antibodies.
Moreover, dose reduction of tacrolimus is especially important in patients with coexisting multiple risk factors.
American Psychological Association (APA)
Krzyżowska, Kinga& Kolonko, Aureliusz& Giza, Piotr& Chudek, Jerzy& Więcek, Andrzej. 2018. Which Kidney Transplant Recipients Can Benefit from the Initial Tacrolimus Dose Reduction?. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126751
Modern Language Association (MLA)
Krzyżowska, Kinga…[et al.]. Which Kidney Transplant Recipients Can Benefit from the Initial Tacrolimus Dose Reduction?. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126751
American Medical Association (AMA)
Krzyżowska, Kinga& Kolonko, Aureliusz& Giza, Piotr& Chudek, Jerzy& Więcek, Andrzej. Which Kidney Transplant Recipients Can Benefit from the Initial Tacrolimus Dose Reduction?. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126751