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Optimization of Ultrasound-Assisted Extraction Followed by Macroporous Resin Purification for Maximal Recovery of Functional Components and Removal of Toxic Components from Ginkgo biloba Leaves
Joint Authors
Zhou, Gui-Sheng
Tang, Yu-Ping
Duan, Jinao
Ma, Jiayan
Wang, Xinmin
Zhang, Jing
Yao, Xin
Jiang, Wei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
In the present study, the process of ultrasound-assisted extraction (UAE) followed by macroporous resin purification was successfully developed to achieve maximal recovery of functional components (flavonoids and ginkgolides) with minimal contents of toxic components (alkylphenols) from Ginkgo biloba leaves.
Three effective extracted factors including HAc%, EtOH%, and UAE power were screened by Plackett–Burman design (PBD).
The important variables were further optimized by rotatable central composite design (RCCD).
By combination of PBD and RCCD, the resulting optimal UAE conditions were as follows: HAc% of 1.8%, EtOH% of 63%, ultrasound power of 303 W, G.
biloba leaves powder amount of 1.0 g (solvent-to-solid ratio 40 mL/g), particle size of 60 mesh, extraction time of 40 min, and extraction temperature of 45°C.
Under the optimum conditions, the yield of flavonoids was 25.1 ± 0.81 mg/g, ginkgolides was 10.6 ± 0.57 mg/g, and alkylphenols was 3.96 ± 0.31 mg/g.
Moreover, the further enriching the functional components and removing toxic components from the obtained extracts of G.
biloba leaves using the above optimum UAE condition was successfully achieved by macroporous resin DA-201.
After column adsorption and desorption on DA-201, the content of total flavonoids was 36.51 ± 1.53%, ginkgolides was 13.24 ± 0.85%, and alkylphenols was 7.0 ± 1.0 μg/g from the obtained dry extracts (drug to extract ratio of 45-50:1) of G.
biloba leaves which were complied with Chinese pharmacopoeias.
American Psychological Association (APA)
Zhou, Gui-Sheng& Ma, Jiayan& Tang, Yu-Ping& Wang, Xinmin& Zhang, Jing& Yao, Xin…[et al.]. 2018. Optimization of Ultrasound-Assisted Extraction Followed by Macroporous Resin Purification for Maximal Recovery of Functional Components and Removal of Toxic Components from Ginkgo biloba Leaves. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1126771
Modern Language Association (MLA)
Zhou, Gui-Sheng…[et al.]. Optimization of Ultrasound-Assisted Extraction Followed by Macroporous Resin Purification for Maximal Recovery of Functional Components and Removal of Toxic Components from Ginkgo biloba Leaves. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1126771
American Medical Association (AMA)
Zhou, Gui-Sheng& Ma, Jiayan& Tang, Yu-Ping& Wang, Xinmin& Zhang, Jing& Yao, Xin…[et al.]. Optimization of Ultrasound-Assisted Extraction Followed by Macroporous Resin Purification for Maximal Recovery of Functional Components and Removal of Toxic Components from Ginkgo biloba Leaves. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1126771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126771