IRW and IQW Reduce Colitis-Associated Cancer Risk by Alleviating DSS-Induced Colonic Inflammation
Joint Authors
Fang, Jun
Jiang, Hongmei
Ma, Yong
Liu, Gang-yu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background and Objective.
Bioactive peptides exert great influence in animals and human health by targeting gastrointestinal tracts.
The colitis model of mice was induced by dextran sulfate sodium (DSS).
Thirty-two 8-week-old mice weighing 23 g on average were randomly assigned to four groups of 8 each: mice fed basal diet (CON), mice fed basal diet with 5% DSS (DSS), mice fed 0.03% IRW with 5% DSS (IRW-DSS), and mice fed 0.03% IRW with 5% DSS (IQW-DSS).
After an adaptation period of 3 days, on day 8, all mice were slaughtered.
Serum samples were collected to determine the level of amino acids; colonic tissue was quick-frozen for the determination of gene expression.
Methods.
The aim of this study was to assess the ability of two kinds of peptides (IRW and IQW) to repair intestinal inflammatory in the DSS-induced model in accordance with serum amino acids and intestinal inflammatory factors.
Results.
The results demonstrated that the addition of IRW and IQW had a mitigating effect on DSS-induced intestinal inflammation.
The level of Asp decreased in the serum of mice supplemented with IRW-DSS (P<0.05), and IQW enhanced the level of Leu, but lowered the level of Ser (P<0.05).
IQW and IRW addition reduced the level of TNF-α and IL-17 (P<0.05).
No other significant effects were observed.
Conclusions.
The present study demonstrated that intracolic administration of IRW and IQW might be a novel option for preventing inflammatory bowel disease via regulating the level of serum amino acid and enhancing the intestinal immune defense.
American Psychological Association (APA)
Ma, Yong& Jiang, Hongmei& Fang, Jun& Liu, Gang-yu. 2019. IRW and IQW Reduce Colitis-Associated Cancer Risk by Alleviating DSS-Induced Colonic Inflammation. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126772
Modern Language Association (MLA)
Ma, Yong…[et al.]. IRW and IQW Reduce Colitis-Associated Cancer Risk by Alleviating DSS-Induced Colonic Inflammation. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126772
American Medical Association (AMA)
Ma, Yong& Jiang, Hongmei& Fang, Jun& Liu, Gang-yu. IRW and IQW Reduce Colitis-Associated Cancer Risk by Alleviating DSS-Induced Colonic Inflammation. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126772