Guava Leaf Extract Diminishes Hyperglycemia and Oxidative Stress, Prevents β-Cell Death, Inhibits Inflammation, and Regulates NF-kB Signaling Pathway in STZ Induced Diabetic Rats
Joint Authors
Jayachandran, Muthukumaran
Vinayagam, Ramachandran
Ambati, Ranga Rao
Xu, Baojun
Chung, Stephen Sum Man
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Traditional Chinese medication has been utilized by Chinese medical practitioners to treat the varied symptoms of diabetes mellitus (DM).
Notably, guava leaf has been used to treat diabetes in Asia.
Our present study has been designed to analyze the action of guava leaf extract (GLE) at the molecular level in treating DM.
A low dose of streptozotocin (STZ) was used to induce experimental diabetes in animals.
Rats were treated with GLE at different concentrations (100, 200, and 400 mg/kg b.w.).
The standard drug glibenclamide (GB) (600 μg/kg b.w.) was used for comparison.
The diabetic rats showed a reduced level of insulin, accompanied by exaggerated levels of blood glucose, lipid peroxidation product, and augmented expressions of inflammatory cytokines, and showed reduced levels of antioxidants compared to the control rats.
Supplementation with GLE counteracted the consequences of STZ.
It suppresses the oxidative stress and inhibits the state of inflammation and the results are almost similar to that of standard drug group (GB group 5).
Our present research, therefore, provides useful data concerning guava leaf extract by a thorough assessment in diabetes management.
Being a natural product, additional analysis on GLE can shed light on finding effective phytochemicals within the field of diabetes mellitus.
American Psychological Association (APA)
Jayachandran, Muthukumaran& Vinayagam, Ramachandran& Ambati, Ranga Rao& Xu, Baojun& Chung, Stephen Sum Man. 2018. Guava Leaf Extract Diminishes Hyperglycemia and Oxidative Stress, Prevents β-Cell Death, Inhibits Inflammation, and Regulates NF-kB Signaling Pathway in STZ Induced Diabetic Rats. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1126774
Modern Language Association (MLA)
Jayachandran, Muthukumaran…[et al.]. Guava Leaf Extract Diminishes Hyperglycemia and Oxidative Stress, Prevents β-Cell Death, Inhibits Inflammation, and Regulates NF-kB Signaling Pathway in STZ Induced Diabetic Rats. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1126774
American Medical Association (AMA)
Jayachandran, Muthukumaran& Vinayagam, Ramachandran& Ambati, Ranga Rao& Xu, Baojun& Chung, Stephen Sum Man. Guava Leaf Extract Diminishes Hyperglycemia and Oxidative Stress, Prevents β-Cell Death, Inhibits Inflammation, and Regulates NF-kB Signaling Pathway in STZ Induced Diabetic Rats. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1126774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126774