The Protective Effects of Enalapril Maleate and Folic Acid Tablets against Contrast-Induced Nephropathy in Diabetic Rats
Joint Authors
Zhu, Boqian
Hou, Jiantong
Tang, Chengchun
Qiao, Yong
Yan, Gaoliang
Liu, Bo
Wang, Dong
Li, Ruifeng
Luo, Erfei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Renal vasoconstriction, oxidative stress, endothelial dysfunction, and apoptosis are the major causes of contrast-induced nephropathy (CIN).
The aim of this study was to evaluate the protective effects of enalapril maleate and folic acid tablets on CIN in diabetic rats.
Methods.
Thirty-two Sprague-Dawley rats were divided into four groups: CIN (C), CIN + enalapril maleate (CE), CIN + folic acid (CF), and CIN + enalapril maleate and folic acid tablets (CEF).
CE, CF, and CEF rats were treated orally with enalapril maleate, folic acid, or enalapril maleate and folic acid tablets, respectively, for 5 days.
CIN was induced in all groups followed by analyzed biochemical parameters, oxidative stress markers, endothelial dysfunction parameters, renal histopathology, and TUNEL staining.
Results.
Serum creatinine, blood urea nitrogen, and malondialdehyde levels were lower in the CEF group than in the C group.
Homocysteine, superoxide dismutase, glutathione peroxidase, and nitric oxide levels were higher in the CEF group than in the C group.
Histopathology scores and percentage of apoptotic kidney cells in the CEF group were significantly decreased compared with those in the C group.
Conclusions.
These results suggest that enalapril maleate and folic acid tablets have a protective effect against CIN in diabetic rats.
American Psychological Association (APA)
Hou, Jiantong& Yan, Gaoliang& Liu, Bo& Zhu, Boqian& Qiao, Yong& Wang, Dong…[et al.]. 2018. The Protective Effects of Enalapril Maleate and Folic Acid Tablets against Contrast-Induced Nephropathy in Diabetic Rats. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126803
Modern Language Association (MLA)
Hou, Jiantong…[et al.]. The Protective Effects of Enalapril Maleate and Folic Acid Tablets against Contrast-Induced Nephropathy in Diabetic Rats. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1126803
American Medical Association (AMA)
Hou, Jiantong& Yan, Gaoliang& Liu, Bo& Zhu, Boqian& Qiao, Yong& Wang, Dong…[et al.]. The Protective Effects of Enalapril Maleate and Folic Acid Tablets against Contrast-Induced Nephropathy in Diabetic Rats. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126803