Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies
Joint Authors
Rasouli-Ghahroudi, Amir Alireza
Akbari, Solmaz
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bone is a metabolically active tissue that renews itself throughout one’s life.
Cytokines along with several hormonal, nutritional, and growth factors are involved in tightly regulated bone remodeling.
Accordingly, vitamin K as a multifunctional vitamin has been recently deemed appreciable as a topic of research as it plays a pivotal role in maintenance of the bone strength, and it has been proved to have a positive impact on the bone metabolism.
Vitamin K exerts its anabolic effect on the bone turnover in different ways such as promoting osteoblast differentiation, upregulating transcription of specific genes in osteoblasts, and activating the bone-associated vitamin k dependent proteins which play critical roles in extracellular bone matrix mineralization.
There is also credible evidence to support the effects of vitamin k2 on differentiation of other mesenchymal stem cells into osteoblast.
The main objective of the present paper is to comprehensively outline the preclinical studies on the properties of vitamin K and its effects on the bone metabolism.
The evidence could shed light on further clinical studies to improve osteogenesis in bone graft surgeries.
American Psychological Association (APA)
Akbari, Solmaz& Rasouli-Ghahroudi, Amir Alireza. 2018. Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126817
Modern Language Association (MLA)
Akbari, Solmaz& Rasouli-Ghahroudi, Amir Alireza. Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1126817
American Medical Association (AMA)
Akbari, Solmaz& Rasouli-Ghahroudi, Amir Alireza. Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126817