Gonadotropin-Releasing Hormone Agonist Corrects Defective Mini-Puberty in Boys with Cryptorchidism: A Prospective Randomized Study

Abstract EN

Introduction.

This prospective study investigated the efficacy of a gonadotropin-releasing hormone agonist (LH-RHa) in restoring defective mini-puberty.

Materials and Methods.

Boys with isolated bilateral cryptorchidism and defective mini-puberty were randomly divided into two groups.

The “surgery only” group underwent a second orchidopexy without hormonal treatment (control).

The “LH-RHa” group received LH-RHa therapy followed by a second orchidopexy.

The number of Ad spermatogonia and the total germ cell count per tubule (S/T) were analyzed.

Results.

Five boys were included in each arm.

In the LH-RHa group, the median S/T increased from 0.11 to 0.42, p=0.04.

In the surgery only group, the median S/T did not change.

In the surgery only group, none of the testes had Ad spermatogonia.

In contrast, in the LH-RHa group, all testes completed the transition from gonocytes to Ad spermatogonia (p=0.008).

Conclusions.

Treatment with LH-RHa was effective in rescuing defective mini-puberty in boys with bilateral cryptorchidism.