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Gonadotropin-Releasing Hormone Agonist Corrects Defective Mini-Puberty in Boys with Cryptorchidism: A Prospective Randomized Study
Joint Authors
Vincel, Beata
Bilius, Vytautas
Dasevicius, Darius
Malcius, Dalius
Jones, Birute
Hadziselimovic, Faruk
Verkauskas, Gilvydas
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
This prospective study investigated the efficacy of a gonadotropin-releasing hormone agonist (LH-RHa) in restoring defective mini-puberty.
Materials and Methods.
Boys with isolated bilateral cryptorchidism and defective mini-puberty were randomly divided into two groups.
The “surgery only” group underwent a second orchidopexy without hormonal treatment (control).
The “LH-RHa” group received LH-RHa therapy followed by a second orchidopexy.
The number of Ad spermatogonia and the total germ cell count per tubule (S/T) were analyzed.
Results.
Five boys were included in each arm.
In the LH-RHa group, the median S/T increased from 0.11 to 0.42, p=0.04.
In the surgery only group, the median S/T did not change.
In the surgery only group, none of the testes had Ad spermatogonia.
In contrast, in the LH-RHa group, all testes completed the transition from gonocytes to Ad spermatogonia (p=0.008).
Conclusions.
Treatment with LH-RHa was effective in rescuing defective mini-puberty in boys with bilateral cryptorchidism.
American Psychological Association (APA)
Vincel, Beata& Verkauskas, Gilvydas& Bilius, Vytautas& Dasevicius, Darius& Malcius, Dalius& Jones, Birute…[et al.]. 2018. Gonadotropin-Releasing Hormone Agonist Corrects Defective Mini-Puberty in Boys with Cryptorchidism: A Prospective Randomized Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1126828
Modern Language Association (MLA)
Vincel, Beata…[et al.]. Gonadotropin-Releasing Hormone Agonist Corrects Defective Mini-Puberty in Boys with Cryptorchidism: A Prospective Randomized Study. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1126828
American Medical Association (AMA)
Vincel, Beata& Verkauskas, Gilvydas& Bilius, Vytautas& Dasevicius, Darius& Malcius, Dalius& Jones, Birute…[et al.]. Gonadotropin-Releasing Hormone Agonist Corrects Defective Mini-Puberty in Boys with Cryptorchidism: A Prospective Randomized Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1126828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126828