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Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet
Joint Authors
Wang, Fuchuan
Cao, Guangming
Yi, Wei
Li, Li
Cao, Xiuzhen
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Metformin has been reported to decrease insulin resistance and is associated with a lower risk of pregnancy-induced hypertension and preeclampsia.
It is widely accepted that the placenta plays a crucial role in the development of preeclampsia.
Our aim is to explore the effect of metformin on preeclampsia.
Study Design.
We examined control diet-fed (isocaloric diet) pregnant mice (CTRL group), pregnant mice fed a high-fat diet (HF group), and high-fat-diet-fed pregnant mice treated with metformin (HF-M group).
The HF mice were fed a high-fat diet six weeks before pregnancy to establish a preeclampsia-like model; then, the group was randomly divided into a HF group and a HF-M group after pregnancy.
Blood pressure, urine protein, pregnancy outcomes, protein expression, and histopathological changes in the placentas of all groups were examined and statistically analysed.
Results.
We observed that metformin significantly improved high blood pressure, proteinuria, and foetal and placental weights in the HF-M group compared with the HF group.
Metformin significantly improved placental labyrinth and foetal vascular development in preeclampsia.
In addition, metformin effectively increased matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) levels in the placenta.
Conclusions.
Our results suggest that metformin can improve preeclamptic symptoms and pregnancy outcomes.
American Psychological Association (APA)
Wang, Fuchuan& Cao, Guangming& Yi, Wei& Li, Li& Cao, Xiuzhen. 2019. Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1126835
Modern Language Association (MLA)
Wang, Fuchuan…[et al.]. Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1126835
American Medical Association (AMA)
Wang, Fuchuan& Cao, Guangming& Yi, Wei& Li, Li& Cao, Xiuzhen. Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1126835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126835