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Bauhinia variegata candida Fraction Induces Tumor Cell Death by Activation of Caspase-3, RIP, and TNF-R1 and Inhibits Cell Migration and Invasion In Vitro
Joint Authors
Ribeiro, R. I. M. A.
Romão, Wanderson
Santos, K. M.
Gomes, I. N. F.
Silva-Oliveira, R. J.
Pinto, F. E.
Oliveira, B. G.
Chagas, R. C. R.
Reis, Rui M.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Metastasis remains the most common cause of death in cancer patients.
Inhibition of metalloproteinases (MMPs) is an interesting approach to cancer therapy because of their role in the degradation of extracellular matrix (ECM), cell-cell, and cell-ECM interactions, modulating key events in cell migration and invasion.
Herein, we show the cytotoxic and antimetastatic effects of the third fraction (FR3) from Bauhinia variegata candida (Bvc) stem on human cervical tumor cells (HeLa) and human peripheral blood mononuclear cells (PBMCs).
FR3 inhibited MMP-2 and MMP-9 activity, indicated by zymogram.
This fraction was cytotoxic to HeLa cells and noncytotoxic to PBMCs and decreased HeLa cell migration and invasion.
FR3 is believed to stimulate extrinsic apoptosis together with necroptosis, assessed by western blotting.
FR3 inhibited MMP-2 activity in the HeLa supernatant, differently from the control.
The atomic mass spectrometry (ESI-MS) characterization suggested the presence of glucopyranosides, D-pinitol, fatty acids, and phenolic acid.
These findings provide insight suggesting that FR3 contains components with potential tumor-selective cytotoxic action in addition to the action on the migration of tumor cells, which may be due to inhibition of MMPs.
American Psychological Association (APA)
Santos, K. M.& Gomes, I. N. F.& Silva-Oliveira, R. J.& Pinto, F. E.& Oliveira, B. G.& Chagas, R. C. R.…[et al.]. 2018. Bauhinia variegata candida Fraction Induces Tumor Cell Death by Activation of Caspase-3, RIP, and TNF-R1 and Inhibits Cell Migration and Invasion In Vitro. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126859
Modern Language Association (MLA)
Santos, K. M.…[et al.]. Bauhinia variegata candida Fraction Induces Tumor Cell Death by Activation of Caspase-3, RIP, and TNF-R1 and Inhibits Cell Migration and Invasion In Vitro. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1126859
American Medical Association (AMA)
Santos, K. M.& Gomes, I. N. F.& Silva-Oliveira, R. J.& Pinto, F. E.& Oliveira, B. G.& Chagas, R. C. R.…[et al.]. Bauhinia variegata candida Fraction Induces Tumor Cell Death by Activation of Caspase-3, RIP, and TNF-R1 and Inhibits Cell Migration and Invasion In Vitro. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126859