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Hepatoid Adenocarcinoma of Stomach: Emphasis on the Clinical Relationship with Alpha-Fetoprotein-Positive Gastric Cancer
Joint Authors
Chen, Er-Bao
Wei, Yi-Chou
Liu, Hai-Ning
Tang, Cheng
Liu, Meng-Ling
Peng, Ke
Liu, Tianshu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
Both hepatoid adenocarcinoma of stomach (HAS) and alpha-fetoprotein-positive gastric cancer (AFPGC) are rare but aggressive subtypes of gastric cancer, but few studies focus on the clinicopathologic differences and prognostic factors between them because of their rarity and histologic overlap.
And the significance of AFP level in HAS prognosis was not well studied.
Methods.
41 patients with AFPGC and 52 patients with HAS were included in this study.
The clinicopathologic features were compared by Chi-square analysis.
Prognostic factors for overall survival (OS) and disease-free survival (DFS) were analyzed with the Kaplan-Meier method.
Results.
The patients with HAS were of a younger age compared with AFPGC, and nearly 60% of tumor located in the gastric antrum and the gastric fundus of cardia.
The OS of AFPGC was shorter than that of HAS, due to a higher rate of metastasis.
Furthermore, the survival analysis showed that HAS with high AFP expression (AFPHigh HAS) had a significantly poorer OS compared to HAS with low AFP expression (AFPLow HAS) (P=0.046).
Conclusions.
Compared with AFPGC, the patients of HAS were of a younger age and had less rate of liver and other organ metastasis.
The serum AFP level was a sensitive prognostic indicator for OS.
Therefore, much attention should be paid to AFPHigh HAS in clinical practice.
American Psychological Association (APA)
Chen, Er-Bao& Wei, Yi-Chou& Liu, Hai-Ning& Tang, Cheng& Liu, Meng-Ling& Peng, Ke…[et al.]. 2019. Hepatoid Adenocarcinoma of Stomach: Emphasis on the Clinical Relationship with Alpha-Fetoprotein-Positive Gastric Cancer. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126877
Modern Language Association (MLA)
Chen, Er-Bao…[et al.]. Hepatoid Adenocarcinoma of Stomach: Emphasis on the Clinical Relationship with Alpha-Fetoprotein-Positive Gastric Cancer. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126877
American Medical Association (AMA)
Chen, Er-Bao& Wei, Yi-Chou& Liu, Hai-Ning& Tang, Cheng& Liu, Meng-Ling& Peng, Ke…[et al.]. Hepatoid Adenocarcinoma of Stomach: Emphasis on the Clinical Relationship with Alpha-Fetoprotein-Positive Gastric Cancer. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126877