PTEN Inhibits Inflammatory Bone Loss in Ligature-Induced Periodontitis via IL1 and TNF-α
Joint Authors
Fu, Chuanyun
Wei, Zhimin
Zhang, Dongsheng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Phosphatase and tensin homolog (PTEN) is a critical regulator of tumorigenesis and bone remodeling, which is also found expressed in the periodontal tissues.
Periodontitis is one of the most common oral diseases and associated with alveolar bone resorption and tooth loosening in adults.
However, the functional relevance of PTEN in periodontitis remains unclear.
Here, we report that PTEN plays an essential role in periodontitis.
The in vivo results of our study showed a significant decrease of PTEN in the ligature-induced mouse periodontitis model.
The function of PTEN in the macrophages was shown to be associated with inflammatory factors interleukin 1 (IL1) and tumor necrosis factor (TNF-α) by using overexpression and silence methods.
Further mechanistic studies indicated lack of PTEN-activated IL1 and TNF-α, which increased the number of osteoclasts and led to alveolar bone erosion and loss.
Moreover, PTEN nanoparticles could directly inhibit the inflammatory process and bone erosion, suggesting a controlling role of PTEN during bone remodeling.
All these data identified the novel function of PTEN as a key factor in periodontitis and bone remodeling.
American Psychological Association (APA)
Fu, Chuanyun& Wei, Zhimin& Zhang, Dongsheng. 2019. PTEN Inhibits Inflammatory Bone Loss in Ligature-Induced Periodontitis via IL1 and TNF-α. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126884
Modern Language Association (MLA)
Fu, Chuanyun…[et al.]. PTEN Inhibits Inflammatory Bone Loss in Ligature-Induced Periodontitis via IL1 and TNF-α. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126884
American Medical Association (AMA)
Fu, Chuanyun& Wei, Zhimin& Zhang, Dongsheng. PTEN Inhibits Inflammatory Bone Loss in Ligature-Induced Periodontitis via IL1 and TNF-α. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126884