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Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy
Joint Authors
Plange, Niklas
Bienert, Marion
Remky, Andreas
Kuerten, D.
Arend, Kay Oliver
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Ischemic ocular disorders may be treated by hypervolemic hemodilution.
The presumed therapeutic benefit is based on a volume effect and improved rheological factors.
The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION).
Methods.
24 patients with acute NAION were included.
Retrobulbar hemodynamics were measured using color Doppler imaging before and 15 min after intravenous infusion of 250 cc 10% hydroxyethyl starch (HES).
Peak systolic velocity (PSV), end diastolic velocity (EDV), and Pourcelot’s resistive index (RI) were measured in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs).
Results.
After infusion of HES blood flow velocities significantly increased in the CRA (PSV from 7.53±2.33 to 8.32±2.51 (p<0.001); EDV from 2.16±0.56 to 2.34±0.55 (p<0.05)) and in the PCAs (PSV from 7.18±1.62 to 7.56±1.55 (p<0.01); EDV from 2.48±0.55 to 2.66±0.6 cm/sec (p<0.01)).
The RI of all retrobulbar vessels remained unaffected.
Blood pressure and heart rate remained unchanged.
Conclusions.
Hypervolemic hemodilution has an acute effect on blood flow velocities in the CRA and PCAs in NAION patients.
Increased blood flow in the arteries supplying the optic nerve head may lead to a better perfusion in NAION patients.
This trial is registered with DRKS00012603.
American Psychological Association (APA)
Bienert, Marion& Plange, Niklas& Remky, Andreas& Arend, Kay Oliver& Kuerten, D.. 2018. Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126885
Modern Language Association (MLA)
Bienert, Marion…[et al.]. Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1126885
American Medical Association (AMA)
Bienert, Marion& Plange, Niklas& Remky, Andreas& Arend, Kay Oliver& Kuerten, D.. Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126885