Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis
Joint Authors
Ling, Ling
Gao, Feifei
Zhang, Qinglin
He, Tao
Zhao, Yi
Xing, Yiqiao
Yu, Yifeng
Ji, Kaibao
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The aim of this study was to assess the retinal and choroidal microvasculature features using optical coherence tomography angiography (OCTA) in patients with retinitis pigmentosa (RP).
Methods.
This study was a meta-analysis of relevant published studies that were included after a comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases.
Mean difference (MD) with a 95% confidence interval was used to assess continuous variable outcomes.
Heterogeneity was evaluated using the chi-squared test based on the values of P and I2.
Results.
Seven studies were included in this meta-analysis.
The vessel density values measured in the superficial and deep foveal zones of RP patients using OCTA were significantly lower than the recorded values in the control groups (MD = −3.58, P=0.04; MD = −4.93, P=0.02, respectively).
The superficial and deep parafoveal vessel density values measured with OCTA were also significantly lower in RP patients than in control groups (MD = −9.09, P<0.00001; MD = −10.74, P<0.00001, respectively); for choriocapillaris vessel density, there was no statistically significant difference between RP patients and controls (MD = −1.33, P=0.09).
The deep foveal avascular zone (FAZ) was significantly larger in RP patients than in controls (MD = 0.15, P=0.01), whereas there was no significant difference in the superficial foveal avascular zones in the two groups (MD = 0.08, P=0.11).
Conclusions.
We showed that retinal and choroidal vessels were attenuated in RP patients.
Additionally, we revealed that the FAZ was larger in RP patients, especially the deep FAZ.
OCTA may become a useful modality in the diagnosis and monitoring of patients with RP.
American Psychological Association (APA)
Ling, Ling& Gao, Feifei& Zhang, Qinglin& He, Tao& Zhao, Yi& Xing, Yiqiao…[et al.]. 2019. Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1126896
Modern Language Association (MLA)
Ling, Ling…[et al.]. Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1126896
American Medical Association (AMA)
Ling, Ling& Gao, Feifei& Zhang, Qinglin& He, Tao& Zhao, Yi& Xing, Yiqiao…[et al.]. Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1126896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126896