MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1

Abstract EN

MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets.

In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC.

Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis.

In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients.

Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in in vitro, as well as in vivo, tumor growth and metastasis in nude mice models bearing human HCC tumors.

In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells.

In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.