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Dihydromyricetin Ameliorates Cardiac IschemiaReperfusion Injury through Sirt3 Activation
Joint Authors
Qi, Xin
Wei, Liping
Sun, Xuseng
Zhang, Yufan
Li, Yuanyang
Xu, Yue
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
During myocardial infarction, quickly opening the occluded coronary artery is a major method to save the ischemic myocardium.
However, it also induces reperfusion injury, resulting in a poor prognosis.
Alleviating the reperfusion injury improves the prognosis of the patients.
Dihydromyricetin (DHM), a major component in the Ampelopsis grossedentata, has numerous biological functions.
This study aims to clarify the effects of DHM under the ischemia/reperfusion (I/R) condition.
We elucidated the role of Sirt3 in the cardiomyocyte response to DHM based on the hearts and primary cardiomyocytes.
Cardiac function, mitochondrial biogenesis, and infarct areas were examined in the different groups.
We performed Western blotting to detect protein expression levels after treatments.
In an in vitro study, primary cardiomyocytes were treated with Hypoxia/Reoxygenation (H/R) to simulate the I/R.
DHM reduced the infarct area and improved cardiac function.
Furthermore, mitochondrial dysfunction was alleviated after DHM treatment.
Moreover, DHM alleviated oxidative stress indicated by decreased ROS and MnSOD.
However, the beneficial function of DHM was abolished after removing the Sirt3.
On the other hand, the mitochondrial function was improved after DHM intervention in vitro study.
Interestingly, Sirt3 downregulation inhibited the beneficial function of DHM.
Therefore, the advantages of DHM are involved in the improvement of mitochondrial function and decreased oxidative stress through the upregulation of Sirt3.
DHM offers a promising therapeutic avenue for better outcome in the patients with cardiac I/R injury.
American Psychological Association (APA)
Wei, Liping& Sun, Xuseng& Qi, Xin& Zhang, Yufan& Li, Yuanyang& Xu, Yue. 2019. Dihydromyricetin Ameliorates Cardiac IschemiaReperfusion Injury through Sirt3 Activation. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126938
Modern Language Association (MLA)
Wei, Liping…[et al.]. Dihydromyricetin Ameliorates Cardiac IschemiaReperfusion Injury through Sirt3 Activation. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126938
American Medical Association (AMA)
Wei, Liping& Sun, Xuseng& Qi, Xin& Zhang, Yufan& Li, Yuanyang& Xu, Yue. Dihydromyricetin Ameliorates Cardiac IschemiaReperfusion Injury through Sirt3 Activation. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126938