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Rectal Cancer: Redox State of Venous Blood and Tissues of Blood Vessels from Electron Paramagnetic Resonance and Its Correlation with the Five-Year Survival
Joint Authors
Gafurov, Marat
Burlaka, A. P.
Vovk, A. V.
Burlaka, A. A.
Lukin, S. N.
Iskhakova, K. B.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A role of pro- and antioxidants for reducing rectal cancer (RC) incidence in operative, preoperative, and postoperative treatments is still disputable and controversial.
The redox state of venous blood and tissues of blood vessels of 60 patients with RC (T2-4N0-2M0G2) and 20 donors is studied by means of the conventional and spin-trapping electron paramagnetic resonance (EPR).
The intensity of the signals from ceruloplasmin (CP), transferrin (TF), and labile iron pool (LIP) at temperature T = 77 K as well as superoxide generation rate and nitric oxide (NO) levels at T = 300 K is measured.
The reduced CP and TF activity and decreased NO levels increased LIP levels and superoxide-generating rates are detected in blood species.
Correlation analysis for the five-year survival rate as a function of the extracted values is done.
The results show that the intensities of the corresponding EPR signals from the “native” and “trapped” paramagnetic centers can be potentially used for the understanding of the molecular mechanisms underlying the RC progression and treatment.
American Psychological Association (APA)
Burlaka, A. P.& Vovk, A. V.& Burlaka, A. A.& Gafurov, Marat& Iskhakova, K. B.& Lukin, S. N.. 2018. Rectal Cancer: Redox State of Venous Blood and Tissues of Blood Vessels from Electron Paramagnetic Resonance and Its Correlation with the Five-Year Survival. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1126949
Modern Language Association (MLA)
Burlaka, A. P.…[et al.]. Rectal Cancer: Redox State of Venous Blood and Tissues of Blood Vessels from Electron Paramagnetic Resonance and Its Correlation with the Five-Year Survival. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1126949
American Medical Association (AMA)
Burlaka, A. P.& Vovk, A. V.& Burlaka, A. A.& Gafurov, Marat& Iskhakova, K. B.& Lukin, S. N.. Rectal Cancer: Redox State of Venous Blood and Tissues of Blood Vessels from Electron Paramagnetic Resonance and Its Correlation with the Five-Year Survival. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1126949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126949