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In Vitro Susceptibility of Mycobacterium abscessus and Mycobacterium fortuitum Isolates to 30 Antibiotics
Joint Authors
Shen, Yaojie
Wang, Xuyang
Jin, Jialin
Wu, Jing
Zhang, Xuelian
Chen, Jiazhen
Zhang, Wenhong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Nontuberculous mycobacteria (NTM) cause various diseases in humans and animals.
Recently, the prevalence of NTM-related disease has been on the rise, becoming an emerging public health problem.
The aim of this study was to determine the antibiotic susceptibility profiles of clinical isolates of Mycobacterium abscessus and Mycobacterium fortuitum.
Methods.
We performed susceptibility tests on 37 clinical NTM isolates to 30 antibiotics with the microdilution method recommended by the Clinical and Laboratory Standards Institute.
Results.
Both M.
abscessus and M.
fortuitum were highly resistant to antitubercular drugs such as isoniazid, rifampin, ethambutol, clofazimine, ethionamide, and rifabutin.
M.
abscessus showed the lowest resistant rates to cefoxitin (10%), azithromycin (10%), amikacin (10%), and clarithromycin (20%) and very high resistant to sulfamethoxazole, vancomycin, oxacillin, clindamycin, and all fluoroquinolones.
M.
fortuitum showed low resistance to tigecycline (0%), tetracycline (0%), cefmetazole (12%), imipenem (12%), linezolid (18%), and the aminoglycosides amikacin (0%), tobramycin (0%), neomycin (0%), and gentamycin (24%).
Conclusion.
Amikacin, cefoxitin, and azithromycin have the highest in vitro activity against M.
abscessus.
Isolates of M.
fortuitum need to be individually evaluated for drug susceptibility before choosing an effective antimicrobial regimen for treatment of infections.
American Psychological Association (APA)
Shen, Yaojie& Wang, Xuyang& Jin, Jialin& Wu, Jing& Zhang, Xuelian& Chen, Jiazhen…[et al.]. 2018. In Vitro Susceptibility of Mycobacterium abscessus and Mycobacterium fortuitum Isolates to 30 Antibiotics. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126979
Modern Language Association (MLA)
Shen, Yaojie…[et al.]. In Vitro Susceptibility of Mycobacterium abscessus and Mycobacterium fortuitum Isolates to 30 Antibiotics. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1126979
American Medical Association (AMA)
Shen, Yaojie& Wang, Xuyang& Jin, Jialin& Wu, Jing& Zhang, Xuelian& Chen, Jiazhen…[et al.]. In Vitro Susceptibility of Mycobacterium abscessus and Mycobacterium fortuitum Isolates to 30 Antibiotics. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126979