Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study
Joint Authors
Laghmich, Achraf
Alaoui Ismaili, Fatima Zahra
Barakat, Amina
Ghailani Nourouti, Naima
Bennani Mechita, Mohcine
Zian, Zeineb
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Consanguinity is a social behavior characterized by the arrangement of marriages between relatives.
It coincides generally with the geographic distribution of recessive genetic diseases as it increases the likelihood of homozygosis and, consequently, the incidence of their pathologies in the population.
In this pilot study, we assess the effect of inbreeding on the burden of hemoglobinopathies in Northern Morocco.
From January 2016 to December 2018, 197 children born in the studied region to three ancestral generations and diagnosed with hemoglobinopathies were subject to investigation.
The rate of consanguinity in the parents’ generation of children with hemoglobinopathies was 50.25%, with first cousin marriages accounting for 68.69% of consanguineous unions (FI = 0.02).
The corresponding rates in the general population, based on a sample of N = 900, were 29.67% and 82.02%, respectively.
The marriages between first cousins are the most common among the other types of consanguineous unions.
Our study propounds that consanguinity substantially contributes to the hemoglobinopathy burden in the studied region and has changed little over time.
Refraining from consanguineous marriages and detecting couples at risk could contribute to the reduction of the incidence of genetic diseases in our country.
American Psychological Association (APA)
Laghmich, Achraf& Alaoui Ismaili, Fatima Zahra& Zian, Zeineb& Barakat, Amina& Ghailani Nourouti, Naima& Bennani Mechita, Mohcine. 2019. Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1126986
Modern Language Association (MLA)
Laghmich, Achraf…[et al.]. Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1126986
American Medical Association (AMA)
Laghmich, Achraf& Alaoui Ismaili, Fatima Zahra& Zian, Zeineb& Barakat, Amina& Ghailani Nourouti, Naima& Bennani Mechita, Mohcine. Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1126986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126986