miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wntβ-Catenin Activation
Joint Authors
Lin, Changmin
Zeng, Yang
Li, Haihong
Cai, Bozhi
Huang, Keng
Yuan, Yanping
Liu, Yang
Zhang, Huan
Lin, En
Xu, Yanming
Li, Yu
Ningxia, Zhu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Dermal papilla (DP) cells play a vital role in hair follicle (HF) development and postnatal hair cycling.
However, the abilities are lost on further culture.
Recent studies have demonstrated significant influences of posttranscriptional regulation by microRNA (miRNA) on HF development.
The current study aims to investigate how miRNAs regulate Wnt/β-catenin to control HF inductivity of DP cells by performing microarray analysis in early- and late-passage DP cells and transfecting with miRNAs inhibitor or mimic.
Results showed early-passage DP cells strongly expressed miRNAs related to inhibition of noncanonical Wnt pathways.
In late-passage DP cells, miRNAs capable of inhibiting the canonical Wnt/β-catenin pathway were upregulated, in addition to the miRNAs targeting the noncanonical Wnt pathway.
Moreover, we verified that β-catenin expression was downregulated by miR-195-5p overexpression in dose manner.
Meanwhile LRP6 expression was downregulated in both protein and mRNA as well as the genes involved in the hair inductivity of DP cells.
These results suggest that the appearance of miRNAs that suppress the Wnt/β-catenin pathway may be responsible for the loss of ability of DP cells in culture and miR-195-5p is the potential key factor involved in regulating HF inductivity of DP cells.
American Psychological Association (APA)
Ningxia, Zhu& Huang, Keng& Liu, Yang& Zhang, Huan& Lin, En& Zeng, Yang…[et al.]. 2018. miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wntβ-Catenin Activation. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126991
Modern Language Association (MLA)
Ningxia, Zhu…[et al.]. miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wntβ-Catenin Activation. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1126991
American Medical Association (AMA)
Ningxia, Zhu& Huang, Keng& Liu, Yang& Zhang, Huan& Lin, En& Zeng, Yang…[et al.]. miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wntβ-Catenin Activation. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126991
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126991