Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis
Joint Authors
Chen, Chong
Rong, Tianhua
Li, Zheng
Shen, Jianxiong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ankylosing spondylitis (AS) is a form of arthritis that can lead to fusion of vertebrae and sacroiliac joints following syndesmophyte formation.
The etiology of this painful disease remains poorly defined due to its complex genetic background.
There are no commonly accepted methods for early diagnosis of AS, nor are there any effective or efficient clinical treatments.
Several noncoding RNAs (ncRNAs) have been linked to AS pathogenesis and inflammation via selective binding of their downstream targets.
However, major gaps in knowledge remain to be filled before such findings can be translated into clinical treatments for AS.
In this review, we outline recent findings that demonstrate essential roles of ncRNAs in AS mediated via multiple signaling pathways such as the Wnt, transforming growth factor-β/bone morphogenetic protein, inflammatory, T-cell prosurvival, and nuclear factor-κB pathways.
The summary of these findings provides insight into the molecular mechanisms by which ncRNAs can be targeted for AS diagnosis and the development of therapeutic drugs against a variety of autoimmune diseases.
American Psychological Association (APA)
Chen, Chong& Rong, Tianhua& Li, Zheng& Shen, Jianxiong. 2019. Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127006
Modern Language Association (MLA)
Chen, Chong…[et al.]. Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1127006
American Medical Association (AMA)
Chen, Chong& Rong, Tianhua& Li, Zheng& Shen, Jianxiong. Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127006