Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain
Joint Authors
Jiang, Wenkai
Ni, Longxing
Sun, Shukai
Sun, Jiangxing
Wang, Wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The trigeminal ganglion (TG) refers to sensory neurons bodies that innervate the spinal cord and peripheral axons that innervate teeth.
The tetrodotoxin-sensitive sodium (NA) channels (Nav1.7) play important roles in the pathophysiology of pain.
In this study, we investigated the TG expression of Nav1.7 and extracellular signal-regulated kinase (ERK) in a rat model of pulpitis to explore the correlation between these channels and inflammatory pain.
Pulpitis was confirmed by hematoxylin-eosin staining.
In this study, we demonstrated that the reflex of rats to mechanical stimulation increases after pulp exposure and that the exposed rat molar pulp can upregulate the expression of Nav1.7 and ERK in the rat TG.
Three days after rat pulp exposure, the expression levels of the two ion channels in the TG increased.
TG target injection of PF04856264, a Nav1.7 inhibitor, dose-dependently increased the mechanical pain threshold and was able to inhibit ERK expression.
TG target injection of PD98059, an ERK inhibitor, dose-dependently increased the mechanical pain threshold.
These factors simultaneously resulted in the highest production.
In this study, with the established link to inflammatory pain, we found that Nav1.7 and ERK both play important roles in the induction of inflammatory pain caused by pulpitis.
We also found a correlation between the expression levels of Nav1.7 and ERK and the degree of inflammatory pain.
Furthermore, ERK signaling pathways were promoted by the Nav1.7 in TG after pulpitis.
American Psychological Association (APA)
Sun, Shukai& Sun, Jiangxing& Jiang, Wenkai& Wang, Wei& Ni, Longxing. 2019. Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1127047
Modern Language Association (MLA)
Sun, Shukai…[et al.]. Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1127047
American Medical Association (AMA)
Sun, Shukai& Sun, Jiangxing& Jiang, Wenkai& Wang, Wei& Ni, Longxing. Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1127047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127047