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Vildagliptin Can Alleviate Endoplasmic Reticulum Stress in the Liver Induced by a High Fat Diet
Joint Authors
Ma, Xiaoqing
Du, Wenhua
Shao, Shanshan
Yu, Chunxiao
Zhou, Lingyan
Jing, Fei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
We investigated whether a DDP-4 inhibitor, vildagliptin, alleviated ER stress induced by a high fat diet and improved hepatic lipid deposition.
Methods.
C57BL/6 mice received standard chow diet (CD), high fat diet (HFD), and HFD administered with vildagliptin (50 mg/Kg) (V-HFD).
After administration for 12 weeks, serum alanine aminotransferase, glucose, cholesterol, triglyceride, and insulin levels were analyzed.
Samples of liver underwent histological examination and transmission electron microscopy, real-time PCR for gene expression levels, and western blots for protein expression levels.
ER stress was induced in HepG2 cells with palmitic acid and the effects of vildagliptin were investigated.
Results.
HFD mice showed increased liver weight/body weight (20.27%) and liver triglycerides (314.75%) compared to CD mice, but these decreased by 9.27% and 21.83%, respectively, in V-HFD mice.
In the liver, HFD induced the expression of ER stress indicators significantly, which were obviously decreased by vildagliptin.
In vitro, the expressions of molecular indicators of ER stress were reduced in HepG2 when vildagliptin was administered.
Conclusions.
Vildagliptin alleviates hepatic ER stress in a mouse high fat diet model.
In HepG2 cells, vildagliptin directly reduced ER stress.
Therefore, vildagliptin may be a potential agent for nonalcoholic fatty liver disease.
American Psychological Association (APA)
Ma, Xiaoqing& Du, Wenhua& Shao, Shanshan& Yu, Chunxiao& Zhou, Lingyan& Jing, Fei. 2018. Vildagliptin Can Alleviate Endoplasmic Reticulum Stress in the Liver Induced by a High Fat Diet. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127049
Modern Language Association (MLA)
Ma, Xiaoqing…[et al.]. Vildagliptin Can Alleviate Endoplasmic Reticulum Stress in the Liver Induced by a High Fat Diet. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1127049
American Medical Association (AMA)
Ma, Xiaoqing& Du, Wenhua& Shao, Shanshan& Yu, Chunxiao& Zhou, Lingyan& Jing, Fei. Vildagliptin Can Alleviate Endoplasmic Reticulum Stress in the Liver Induced by a High Fat Diet. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127049