Gingko biloba Extract (EGb) Inhibits Oxidative Stress in Neuro 2A Cells Overexpressing APPsw
Joint Authors
Chen, Le
Zhang, Chenghong
Han, Ying
Meng, Xianyi
Zhang, Ying
Chu, Haiying
Ma, Haiying
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a common neurodegenerative disease.
Abundant evidence demonstrates that oxidative stress may be not only an early event in this disease, but also a key factor in the pathogenesis of AD.
Ginkgo biloba extract (EGb) has a strong ability to scavenge oxygen free radicals and supply hydrogen.
The present study aims to investigate the effects of EGb on Neuro 2A cells transfected with Swedish mutant APP (APPsw).
Stably transfected Neuro 2A cell lines expressing human wild-type APP (APP695), APPsw, or empty vector(neo) pEGFP-N2 were treated with 100 μg/ml EGb for 0, 2, 4, 6, 8, and 10 h.
Oxidative stress was assessed by measuring free radicals and the activities of antioxidant enzymes.
Our studies showed that EGb treatment reduced the production of reactive oxygen species (ROS) and the levels of malondialdehyde (MDA) significantly while total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were enhanced in Neuro 2A cells overexpressing APPsw.
Meanwhile, Aβ levels in these cells were also reduced compared to the levels in untreated cells and control cells (empty vector(neo) pEGFP-N2).
These findings suggest that EGb can reduce oxidative stress by decreasing free radical and enhancing antioxidant status, further leading to reduced Aβ aggregation; EGb might be a potential therapeutic agent for Alzheimer’s disease (AD).
American Psychological Association (APA)
Chen, Le& Zhang, Chenghong& Han, Ying& Meng, Xianyi& Zhang, Ying& Chu, Haiying…[et al.]. 2019. Gingko biloba Extract (EGb) Inhibits Oxidative Stress in Neuro 2A Cells Overexpressing APPsw. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127070
Modern Language Association (MLA)
Chen, Le…[et al.]. Gingko biloba Extract (EGb) Inhibits Oxidative Stress in Neuro 2A Cells Overexpressing APPsw. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1127070
American Medical Association (AMA)
Chen, Le& Zhang, Chenghong& Han, Ying& Meng, Xianyi& Zhang, Ying& Chu, Haiying…[et al.]. Gingko biloba Extract (EGb) Inhibits Oxidative Stress in Neuro 2A Cells Overexpressing APPsw. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127070