![](/images/graphics-bg.png)
Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis
Joint Authors
Zanoteli, Edmar
Camargo, Leonardo Valente de
Carvalho, Mary Souza de
Shinjo, Samuel Katsuyuki
Oliveira, Acary Souza Bulle de
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Sporadic inclusion body myositis (sIBM) is considered the most common acquired myopathy aged over 50 years.
The disease is characterized by a particular process of muscle degeneration characterized by abnormal deposit of protein aggregates in association with inflammation.
The aim of this study was to present clinical and muscle histopathological findings, including immunostaining for LC3B, p62, α-synuclein, and TDP-43, in 18 patients with sIBM.
The disease predominated in males (61%) and European descendants, with onset of clinical manifestations around 59 years old.
The most common symptoms were muscle weakness, falls, dysphagia, and weight loss.
Hypertension was the main comorbidity.
Most of the cases presented with paresis predominantly proximal in lower limbs and distal in upper limbs.
Immunosuppressive treatment showed to be not effective.
Muscle histological findings included dystrophic changes, endomysial inflammation, increased lysosomal activity, and presence of rimmed vacuoles and of beta-amyloid accumulation, in addition to high frequency of mitochondrial changes.
There was increased expression of LC3B, p62, α-synuclein, and TDP-43 in muscle biopsies.
The sIBM has characteristic clinical and histological findings, and the use of degeneration and autophagic markers can be useful for the diagnosis.
American Psychological Association (APA)
Camargo, Leonardo Valente de& Carvalho, Mary Souza de& Shinjo, Samuel Katsuyuki& Oliveira, Acary Souza Bulle de& Zanoteli, Edmar. 2018. Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1127074
Modern Language Association (MLA)
Camargo, Leonardo Valente de…[et al.]. Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1127074
American Medical Association (AMA)
Camargo, Leonardo Valente de& Carvalho, Mary Souza de& Shinjo, Samuel Katsuyuki& Oliveira, Acary Souza Bulle de& Zanoteli, Edmar. Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1127074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127074