The Central Role of the Inflammatory Response in Understanding the Heterogeneity of Sepsis-3
Joint Authors
Ding, Renyu
Meng, Yulan
Ma, Xiaochun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In sepsis-3, in contrast with sepsis-1, the definition “systemic inflammatory response” has been replaced with “dysregulated host response”, and “systemic inflammatory response syndrome” (SIRS) has been replaced with “sequential organ failure assessment” (SOFA).
Although the definition of sepsis has changed, the debate regarding its nature is ongoing.
What are the fundamental processes controlling sepsis-induced inflammation, immunosuppression, or organ failure? In this review, we discuss the heterogeneity of sepsis-3 and address the central role of inflammation in the pathogenesis of sepsis.
An unbalanced pro- and anti-inflammatory response, inflammatory resolution disorder, and persistent inflammation play important roles in the acute and/or chronic phases of sepsis.
Moreover, powerful links exist between inflammation and other host responses (such as the neuroendocrine response, coagulation, and immunosuppression).
We suggest that a comprehensive evaluation of the role of the inflammatory response will improve our understanding of the heterogeneity of sepsis.
American Psychological Association (APA)
Ding, Renyu& Meng, Yulan& Ma, Xiaochun. 2018. The Central Role of the Inflammatory Response in Understanding the Heterogeneity of Sepsis-3. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127084
Modern Language Association (MLA)
Ding, Renyu…[et al.]. The Central Role of the Inflammatory Response in Understanding the Heterogeneity of Sepsis-3. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1127084
American Medical Association (AMA)
Ding, Renyu& Meng, Yulan& Ma, Xiaochun. The Central Role of the Inflammatory Response in Understanding the Heterogeneity of Sepsis-3. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127084