The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases
Joint Authors
Bil-Lula, Iwona
Krzywonos-Zawadzka, Anna
Olejnik, Agnieszka
Franczak, Aleksandra
Kałużna-Oleksy, Marta
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Klotho is a membrane-bound or soluble antiaging protein, whose protective activity is essential for a proper function of many organs.
In 1997, an accidental insertion of a transgene led to creation of transgenic mice with several age-related disorders.
In Klotho-deficient mice, the inherited phenotypes closely resemble human aging, while in an animal model of Klotho overexpression, the lifespan is extended.
Klotho protein is detected mainly in the kidneys and brain.
It is a coreceptor for fibroblast growth factor and hence is involved in maintaining endocrine system homeostasis.
Furthermore, an inhibition of insulin/insulin-like growth factor-1 signaling pathway by Klotho regulates oxidative stress and reduces cell death.
The association between serum Klotho and the classic risk factors, as well as the clinical history of cardiovascular disease, was also shown.
There are a lot of evidences that Klotho deficiency correlates with the occurrence and development of coronary artery disease, atherosclerosis, myocardial infarction, and left ventricular hypertrophy.
Therefore, an involvement of Klotho in the signaling pathways and in regulation of a proper cell metabolism could be a crucial factor in the cardiac and vascular protection.
It is also well established that Klotho protein enhances the antioxidative response via augmented production of superoxide dismutase and reduced generation of reactive oxygen species.
Recent studies have proven an expression of Klotho in cardiomyocytes and its increased expression in stress-related heart injury.
Thus, the antioxidative and antiapoptotic activity of Klotho could be considered as the novel protective factor in cardiovascular disease and heart injury.
American Psychological Association (APA)
Olejnik, Agnieszka& Franczak, Aleksandra& Krzywonos-Zawadzka, Anna& Kałużna-Oleksy, Marta& Bil-Lula, Iwona. 2018. The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases. BioMed Research International،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1127129
Modern Language Association (MLA)
Olejnik, Agnieszka…[et al.]. The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases. BioMed Research International No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1127129
American Medical Association (AMA)
Olejnik, Agnieszka& Franczak, Aleksandra& Krzywonos-Zawadzka, Anna& Kałużna-Oleksy, Marta& Bil-Lula, Iwona. The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1127129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127129