Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature
Joint Authors
Zhang, Junping
Zhou, Huan
Wang, Bin
Yang, Ying-xi
Jia, Qiu-jin
Zhang, Ao
Qi, Zhong-wen
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cardiac remodeling is a self-regulatory response of the myocardium and vasculature under the stressful condition.
Cardiomyocytes (CMs), vascular smooth muscle cells (VSMCs), endothelial cells (ECs), and cardiac fibroblasts (CFs) are all involved in this process, characterized by change of morphological structures and mechanical/chemical activities as well as metabolic patterns.
Despite current development of consciousness, the control of cardiac remodeling remains unsatisfactory, and to further explore the underlying mechanism and seek the optimal therapeutic targets is still the urgent need in clinical practice.
It is now emerging that long noncoding RNAs (lncRNAs) play key regulatory roles in these adverse responses: lncRNA TUG1, AK098656, TRPV1, GAS5, Giver, and Lnc-Ang362 have been indicated in hypertension-related vascular remodeling, H19, TUG1, UCA1, MEG3, APPAT, and lincRNA-p21 in atherosclerosis (AS), and HIF1A-AS1 and Lnc-HLTF-5 in aortic aneurysm (AA).
In addition, Neat1, AK139328, APF, CAIF, AK088388, CARL, MALAT1, HOTAIR, XIST, and NRF are involved in postischemia myocardial remodeling, while Mhrt, Chast, CHRF, ROR, H19, Plscr4, and MIAT are involved in myocardial hypertrophy, and MALAT1, wisper, MEG3, and H19 are involved in extracellular matrix (ECM) reconstitution.
Signaling to specific miRNAs by acting as endogenous sponge (ceRNA) was the main form that regulates the target gene expression during cardiac remodeling.
This review will underline the updates of lncRNAs and lncRNA-miRNA interactions in maladaptive remodeling and also cast light on their potential roles as therapeutic targets, hoping to provide supportive background for following research.
American Psychological Association (APA)
Zhou, Huan& Wang, Bin& Yang, Ying-xi& Jia, Qiu-jin& Zhang, Ao& Qi, Zhong-wen…[et al.]. 2019. Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1127143
Modern Language Association (MLA)
Zhou, Huan…[et al.]. Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1127143
American Medical Association (AMA)
Zhou, Huan& Wang, Bin& Yang, Ying-xi& Jia, Qiu-jin& Zhang, Ao& Qi, Zhong-wen…[et al.]. Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1127143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127143