Vimentin Overexpressions Induced by Cell Hypoxia Promote Vasculogenic Mimicry by Renal Cell Carcinoma Cells
Joint Authors
Lin, Hao
Hong, Yingkai
Huang, Bin
Liu, Xincheng
Zheng, Junhong
Qiu, Shaopeng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Vasculogenic mimicry (VM), the novel approach for tumor cells to obtain blood supply, was reported to be involved in antiangiogenic resistance and poor prognosis in renal cell carcinoma (RCC).
However, the molecular mechanisms underlying VM formed by RCC cells are still not clearly depicted.
In the present study, we found that OS-RC-2 acquired the VM forming ability accompanied with the increased expressions of Vimentin and AXL and decreased expression of E-Cadherin by CoCl2 treatment.
Downregulation of Vimentin by siRNA severely impaired the capability of OS-RC-2 and 786-O to form VM structures induced by cell hypoxia in vitro.
Moreover, knockdown of Vimentin inhibited cell migration and invasion, which could be prompted by hypoxia induction in RCC cells.
In our clear cell RCC tissues, we found that VM was positively correlated with Vimentin overexpression and both predicted poor prognosis.
In conclusion, Vimentin plays an important role in hypoxia induced VM formation of RCC cells and targeted Vimentin might be beneficial for RCC therapy.
American Psychological Association (APA)
Lin, Hao& Hong, Yingkai& Huang, Bin& Liu, Xincheng& Zheng, Junhong& Qiu, Shaopeng. 2019. Vimentin Overexpressions Induced by Cell Hypoxia Promote Vasculogenic Mimicry by Renal Cell Carcinoma Cells. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1127183
Modern Language Association (MLA)
Lin, Hao…[et al.]. Vimentin Overexpressions Induced by Cell Hypoxia Promote Vasculogenic Mimicry by Renal Cell Carcinoma Cells. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1127183
American Medical Association (AMA)
Lin, Hao& Hong, Yingkai& Huang, Bin& Liu, Xincheng& Zheng, Junhong& Qiu, Shaopeng. Vimentin Overexpressions Induced by Cell Hypoxia Promote Vasculogenic Mimicry by Renal Cell Carcinoma Cells. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1127183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127183