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Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions
Joint Authors
Smagin, Dmitry A.
Kovalenko, Irina L.
Galyamina, Anna G.
Kudryavtseva, Natalia N.
Babenko, Vladimir N.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chronic agonistic interactions promote the development of experimental psychopathologies in animals: a depression-like state in chronically defeated mice and the pathology of aggressive behavior in the mice with repeated wins.
The abundant research data indicate that such psychopathological states are associated with significant molecular and cellular changes in the brain.
This paper aims to study the influence of a 20-day period of agonistic interactions on the expression patterns of collagen family genes encoding the proteins which are basic components of extracellular matrix (ECM) in different brain regions of mice using the RNA-Seq database.
Most of differentially expressed collagen genes were shown to be upregulated in the hypothalamus and striatum of chronically aggressive and defeated mice and in the hippocampus of defeated mice, whereas downregulation of collagen genes was demonstrated in the ventral tegmental areas in both experimental groups.
Aberrant expression of collagen genes induced by chronic agonistic interactions may be indicative of specific ECM defects in the brain regions of mice with alternative social experience.
This is the first study demonstrating remodeling of ECM under the development of experimental disorders.
American Psychological Association (APA)
Smagin, Dmitry A.& Galyamina, Anna G.& Kovalenko, Irina L.& Babenko, Vladimir N.& Kudryavtseva, Natalia N.. 2019. Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1127198
Modern Language Association (MLA)
Smagin, Dmitry A.…[et al.]. Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1127198
American Medical Association (AMA)
Smagin, Dmitry A.& Galyamina, Anna G.& Kovalenko, Irina L.& Babenko, Vladimir N.& Kudryavtseva, Natalia N.. Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1127198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127198