Myoferlin, a Membrane Protein with Emerging Oncogenic Roles
Joint Authors
Dong, Yimin
Kang, Honglei
Liu, Huiyong
Wang, Jia
Guo, Qian
Song, Chao
Sun, Yunlong
Zhang, Ya
Zhang, Honghua
Zhang, Zheng
Guan, Hanfeng
Fang, Zhong
Li, Feng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Myoferlin (MYOF), initially identified in muscle cells, is a member of the Ferlin family involved in membrane fusion, membrane repair, and membrane trafficking.
Dysfunction of this protein is associated with muscular dysfunction.
Recently, a growing body of studies have identified MYOF as an oncogenic protein.
It is overexpressed in a variety of human cancers and promotes tumorigenesis, tumor cell motility, proliferation, migration, epithelial to mesenchymal transition, angiogenesis as well as metastasis.
Clinically, MYOF overexpression is associated with poor outcome in various cancers.
It can serve as a prognostic marker of human malignant disease.
MYOF drives the progression of cancer in various processes, including surface receptor transportation, endocytosis, exocytosis, intercellular communication, fit mitochondrial structure maintenance and cell metabolism.
Depletion of MYOF demonstrates significant antitumor effects both in vitro and in vivo, suggesting that targeting MYOF may produce promising clinical benefits in the treatment of malignant disease.
In the present article, we reviewed the physiological function of MYOF as well as its role in cancer, thus providing a general understanding for further exploration of this protein.
American Psychological Association (APA)
Dong, Yimin& Kang, Honglei& Liu, Huiyong& Wang, Jia& Guo, Qian& Song, Chao…[et al.]. 2019. Myoferlin, a Membrane Protein with Emerging Oncogenic Roles. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127252
Modern Language Association (MLA)
Dong, Yimin…[et al.]. Myoferlin, a Membrane Protein with Emerging Oncogenic Roles. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1127252
American Medical Association (AMA)
Dong, Yimin& Kang, Honglei& Liu, Huiyong& Wang, Jia& Guo, Qian& Song, Chao…[et al.]. Myoferlin, a Membrane Protein with Emerging Oncogenic Roles. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127252