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Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats
Joint Authors
Liu, Cun-Zhi
Yang, Jing-Wen
Xiao, Ling-Yong
Wang, Xue-Rui
Ye, Yang
Yang, Na-Na
Yan, Chao-Qun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Alteration of dopamine (DA) and noradrenaline (NA) contributes to cognitive function.
Acupuncture has been shown to affect DA and NA in chronic cerebral hypoperfusion (CCH) rats.
However, the effect of acupuncture on DA-β-hydroxylase (DBH), the biosynthetic enzyme of NA, remains unknown.
In CCH rats we established chronic hypoperfusion by bilateral common carotid artery occlusion (two-vessel occlusion, 2VO) and treated them with acupuncture.
Acupuncture displayed beneficial effects on hippocampus-dependent memory impairments, including nonspatial and spatial memory.
That is also reflected in hippocampus long-term-potentiation (LTP).
Moreover, DBH expression in the hippocampus and DBH activity in cerebrospinal fluid were upregulated after acupuncture treatment.
In conclusion, these in vivo findings suggest that acupuncture exerts a therapeutic effect on hippocampus-dependent memory and hippocampus LTP in CCH rats, which may be partially related to the modulation of DBH in the hippocampus.
American Psychological Association (APA)
Xiao, Ling-Yong& Yang, Jing-Wen& Wang, Xue-Rui& Ye, Yang& Yang, Na-Na& Yan, Chao-Qun…[et al.]. 2018. Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127287
Modern Language Association (MLA)
Xiao, Ling-Yong…[et al.]. Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1127287
American Medical Association (AMA)
Xiao, Ling-Yong& Yang, Jing-Wen& Wang, Xue-Rui& Ye, Yang& Yang, Na-Na& Yan, Chao-Qun…[et al.]. Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127287