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Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidney Transplantation: A Single Centre Experience
Joint Authors
Papalois, Vassilios
Dor, Frank J. M. F.
Bellini, Maria Irene
Charalmpidis, Sotiris
Herbert, Paul Elliot
Bonatsos, Vasileios
Crane, Jeremy
Muthusamy, Anand
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
We present our experience with hypothermic machine perfusion (HMP) versus cold storage (CS) in relation to kidney transplant outcomes.
Methods.
Retrospective analysis of 33 consecutive HMP kidney transplant outcomes matched with those of 33 cold stored: delayed graft function (DGF), length of hospital stay (LOS), estimated glomerular filtration rate (eGFR), and patient and graft survival were compared.
Renal Resistive Indexes (RIs) during HMP in relation to DGF were also analysed.
Results.
In the HMP group, mean HMP time was 5.7 ± 3.9 hours with a mean cold ischaemic time (CIT) of 15 ± 5.6 versus 15.1 ± 5.3 hours in the CS group.
DGF was lower in the HMP group (p=0.041), and donation after Circulatory Death (DCD) was a predictor for DGF (p<0.01).
HMP decreased DGF in DCD grafts (p=0.036).
Patient and graft survival were similar, but eGFR at 365 days was higher in the HMP cohort (p<0.001).
RIs decreased during HMP (p<0.01); 2-hours RI ≥ 0.45 mmHg/mL/min predicted DGF in DCD kidneys (75% sensitivity, 80% specificity; area under the curve 0.78); 2-hours RI ≥ 0.2 mmHg/ml/min predicted DGF in DBD grafts (sensitivity 100%, specificity 91%; area under the curve 0.87).
Conclusion.
HMP decreased DGF compared to CS, offering viability assessment pretransplant and improving one-year renal function of the grafts.
American Psychological Association (APA)
Bellini, Maria Irene& Charalmpidis, Sotiris& Herbert, Paul Elliot& Bonatsos, Vasileios& Crane, Jeremy& Muthusamy, Anand…[et al.]. 2019. Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidney Transplantation: A Single Centre Experience. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127292
Modern Language Association (MLA)
Bellini, Maria Irene…[et al.]. Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidney Transplantation: A Single Centre Experience. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1127292
American Medical Association (AMA)
Bellini, Maria Irene& Charalmpidis, Sotiris& Herbert, Paul Elliot& Bonatsos, Vasileios& Crane, Jeremy& Muthusamy, Anand…[et al.]. Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidney Transplantation: A Single Centre Experience. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127292